Hydroxyprogesterone

Hydroxyprogesterone is intermediate formed in the conversion of cholesterol to cortisol, androgen and estrogens, used in contraception (to prevent pregnancy). Hydroxyprogesterone is also used to treat dysmenorrhea, irregular uterine bleeding and in the management of endometriosis.

Brands
VIO DEPOT HYDROXYPROGESTERONE HYDROXYPROGESTERONE
Adult Dose
Dose: 250 to 500 mg
Single Dose: 380 (375)
Frequency: As recommended.
Route: IM
Instructions: Once a Week
Neonatal
Paedriatic
Characteristics
belongs to Pregnenolone. It belongs to Progesterone agonist pharmacological group on the basis of mechanism of action and also classified in Sex Hormones and Progestin pharmacological group.The Molecular Weight of Hydroxyprogesterone is 428.59.
Contraindications
Hydroxyprogesterone is contraindicated in conditions like Breast cancer,Vaginal bleeding,Hyperlipidemia,Liver carcinoma.
Effects
The severe or irreversible adverse effects of Hydroxyprogesterone, which give rise to further complications include Allergic reaction chest pain pepression.The symptomatic adverse reactions produced by Hydroxyprogesterone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Flatulence, Diarrhea, Local pain, GI upset, Weight gain, Edema, Pre-existing acne & urticaria.
Indications
Hydroxyprogesterone is primarily indicated in conditions like Abortion prevention, Habitual abortion, Preterm labour, and can also be given in adjunctive therapy as an alternative drug of choice in Endometrial cancer.
Interactions
No data regarding the interactions of Hydroxyprogesterone was found.
Interfrence
Measurement of Progesterone in Plasma
Risks
Drug should not be given to Paediatrics, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store Below 40°C. Do not Freeze.
Warnings
Hydroxyprogesterone should not be used during pregnancy or lactation. It should be used with caution in patients with any pre-existing liver disease, diabetes, seizure disorder, kidney disease, heart trouble, asthma or a history of depression, migraines, blood clots, miscarriage or breast cancer or any allergy. Because this medication may increase sensitivity to sunlight, avoid prolonged sun expose, wear a sunscreen and protective clothing when outdoors. Diabetic patients should monitor urine and blood sugar closely while taking this medication as it can reduce glucose tolerance.
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