Dose: 0.357 mg/kg
Single Dose: 0.36 (0.357)
Frequency: As recommended.
Route: PO
Instructions: Initially for Once

Dose: 1 mg/kg
Single Dose: 1 (1)
Frequency: 24 hourly
Route: Oral
Instructions: -

Dose: 1 mg/kg
Single Dose: 1 (1)
Frequency: 24 hourly
Route: Oral
Instructions: -

Hydroflumethiazide also known as Dihydroflumethiazide, Dihydroflumethiazide. . It is of Synthetic origin and belongs to Sulphonamide. It belongs to NaCl cotransport inhibitor pharmacological group on the basis of mechanism of action and also classified in Diuretic Thiazide pharmacological group.The Molecular Weight of Hydroflumethiazide is 331.30. Its pKa is 8.5, 10.0.

Hydroflumethiazide is contraindicated in conditions like Diabetes mellitus,Hypokalaemia.

The severe or irreversible adverse effects of Hydroflumethiazide, which give rise to further complications include Thrombocytopenia, Pancreatitis, Cholestatic jaundice, Photosensitivity, Acute interstitial pulmonary edema, Skin rashes, Atherosclerosis, Necrotising vasculitis.Hydroflumethiazide produces potentially life-threatening effects which include Hyponatremia, Hypokalemia, Cardiac arrhythmias, Abnormal lipid profile, Hypoplastic Anemia. which are responsible for the discontinuation of Hydroflumethiazide therapy.The signs and symptoms that are produced after the acute overdosage of Hydroflumethiazide include Hypotension, Volume depletion, Hypokalemia, Renal failure, Hyponatremia.The symptomatic adverse reactions produced by Hydroflumethiazide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Thirst, Headache, Nausea, Gout, Impotence, Polyuria, Night cramps.

Hydroflumethiazide is primarily indicated in conditions like Disorders of calcium balance, Edema, Heart failure, Hypertension, Oedema, and can also be given in adjunctive therapy as an alternative drug of choice in Diabetes insipidus.

Hydroflumethiazide is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholAlcuronium (Cl)AllopurinolDigoxinHydroflumethiazide may enhance the adverse/toxic effect of Digoxin. This by increasing the risk of hypokalemia. ModerateMonitor for increased toxic effects of Digoxin if Hydroflumethiazide is initiated or the dose is increased. The use of a potassium-sparing diuretic might be considered to minimize potassium loss. Likewise, potassium supplementation, along with careful monitoring of serum potassium and possibly Digoxin concentrations, might be helpful.LithiumPancuronium (Br)Probenecidthiazide diuretics inhibits the uricosuric effects of probencidQuinidineTubocurarine (Cl) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

False Low values in GLC assay of Urinary oestriol

Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Tab Store Below 40°C. Protect from Sunlight and Moisture.

Thiazide diuretics increase sensitivity to sunlight, so avoid prolonged sun exposure, use a sunscreen and wear protective clothing. This medication should be used during pregnancy or lactation only if clearly needed. It should be used with caution in patients with gout or diabetes or any allergies especially to sulfa medications. Avoid any drugs that increase heart rate or cause excitation like decongestants (present in cough or cold products) because it may counter-act the blood pressure medicine.