HYDROCORT HYDROCORT POSTERISAN FORTE HYZONATE HYZONATE HYZONATE MYCONIT-H GENTA-HC HYDROSONE HYDROSONE NEO CORT NEO CORT CORTISPORIN OTOSPORIN DAKTACORT HYDROCORTISONE HYSONE LEVOCORT LEVOCORT CHLOROMYCETIN HC NEO-PHENICOL H.C. SOLU CORTEF SOLU CORTEF SOLU CORTEF CARTILAN CARTILAN CARTILAN GENTICYN-HC GENTICYN-HC LACTICARE-HC LACTICARE-HC DERMISTATE-HC CLIOQUINOL HYDROCORTISONE CLIOQUINOL HYDROCORTISONE HYDROCORTISONE HYDROCORTISONE FUCIDIN-H DERMOSPORIN SOLU-HYDROCORT SOLU-HYDROCORT SOLU-HYDROCORT METHACHLOR METHACHLOR OTOGEN-HC POLYSPORE-HC POLYSPORE-HC MYCON-H CURODERM-H CURODERM-H HY-CORTISONE HY-CORTISONE HY-CORTISONE FUSAC-H FUSAC-H HYDROZOLE HYCORTISONE FUDIC H SECODIC-H COSACORT COSACORT TINEACORT TINEACORT TYCELEX FUSIL-HC FUSIL-HC PATHODERM-H PATHODERM-H CUTIS-HC FUSIDERM-H FOSEDIC-H DERMAFUSE-H MICTRACIN H CORTIVAL CORTIVAL CORTIVAL CORTIVAL HYDRO SOD SUC HYDRO SOD SUC PHUSILAN-H DIPCORT EKSALB GENTACORT CLORAMIDINA H CORTISOL CORTISOL MYCOREX+H NOVISKIN-H FURTIGENT CLARIDERM PLUS IPRACORT IPRACORT ALBICOST UDIC-H DANADERM SIDIK-H LARTEX DERMICON HC GYTRIM HC HYDROGRAY CORTIDERM CORTIDERM BIO-CORT BIO-CORT BIO-CORT HYDROMYCIN CLOZOX H LACTIZAM HY-CIB FUCIROG-H HYDROCORT 1.0% HYDROCORT 1.0% HYDROCORT 1.0% HYDROCORT 2.5% HYDROCORT 2.5% H-CORTISONE H-CORTISONE CLOZOLE-H CARACORT CREAMAZOLE-H FUSIWAY-H COLRIZOL FSID-H FUSID-H FUSIMED-H FUSINEX GEN-COT GEN-COT GEN-COT HYDROHEAL HYDROHEAL HYDROHEAL HYDROVATE HYDROVATE HYDROVATE LACTISAFE-H GYNOZE-HC USIDIN-H

Dose: 100 to 500 mg
Single Dose: 300 (300)
Frequency: 8 hourly
Route: IV
Instructions:

Dose: 6.25 mg/kg
Single Dose: 6.2 (6.25)
Frequency: 6 hourly
Route: Intramuscular
Instructions:

Dose: 5 mg/kg
Single Dose: 5 (5)
Frequency: 6 hourly
Route: Intra Muscular
Instructions: -

Hydrocortisone also known as Hydrocortisona, Hydrocortisona, Hydrocortisona, Hydrocortisona. Hydrocortisone Valerate, Hydrocortisone Valerate are the derivatives of Hydrocortisone. It is of Natural origin and belongs to Steroid. It belongs to Glucocorticoid agonist pharmacological group on the basis of mechanism of action and also classified in Adrenal Cortical Steroids pharmacological group.The Molecular Weight of Hydrocortisone is 362.50. Its pKa is 13.81.

Hydrocortisone is contraindicated in conditions like Ulcers,Systemic infections,Hypersensitivity.

The severe or irreversible adverse effects of Hydrocortisone, which give rise to further complications include Convulsions, Gi bleeding, Telangiectasia, Striae, Glaucoma, Cataract, Pancreatitis, Hypersensitivity reactions, Osteoporosis, Psychosis, Increased intracranial pressure, Growth retardation, Glucose intolerance, Epidermal thinning, Vertebral fractures, Avascular necrosis, Papilloedema, Opthalmic fungal or viral disease, Dendritic corneal ulcers, Thromboembolic disorder, Long bone fractures, Hypokalemic alkalosis, Reduced visual function, Tendon rupture, Intestinal perforation, Opportunistic infections, Addisonian crises, Adrenal atrophy, Increased IOP (intraocular pressure), Subcutaneous atrophy.Hydrocortisone produces potentially life-threatening effects which include Anaphylactoid reactions, Addisonian crises, CHF, Opportunistic infections, Acute pancreatitis, GI hemorrhage. which are responsible for the discontinuation of Hydrocortisone therapy.The signs and symptoms that are produced after the acute overdosage of Hydrocortisone include hypomagnesaemia, Hyperkalemia, Adrenal suppression.The symptomatic adverse reactions produced by Hydrocortisone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Insomnia, Irritation, Allergic reactions, Itching, Burning, Depression, Weight gain, Acne, Euphoria, Menstrual irregularity, Perioral dermatitis, Cushingoid facies, Mood swings, Dryness, Local hypopigmentation, Stinging.

Hydrocortisone is primarily indicated in conditions like Adrenal insufficiency, Anaphylactic reactions, Apthous ulcers, Atopic eczema, Collagen disease, Congenital adrenal hyperplasia, Contact allergic dermatitis, Discoid eczema, Flexural psoriasis, Graft rejection, Hypercalcaemia, Infantile eczema, Inflammation, Irritant dermatitis, Itching, Joint inflammation, Perineal trauma, Seborrheic dermatitis, Shock, Soft tissue inflammation, Status asthmaticus, Ulcerative protocolitis, and can also be given in adjunctive therapy as an alternative drug of choice in Anaphylactic shock, Insect bites, Otitis externa, Sunburn, Ulcerative colitis.

Hydrocortisone is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAminoglutethimideAminoglutethimide accelerates the metabolism of hydrocortisone (reduced effects).AmobarbitalAmlodipine accelerates the metabolism of Hydrocortisone (reduced effects).Amphotericin BIncreased risk of hypokalemia when Amphotericin given with corticosteroids (e.g hydrocortisone). ADVICE: Avoid concomitant use unless corticosteroids needed to control the reactions.MajorAscorbic AcidAspirinhydrocortisone increase the bioavailability of aspirinBismuth SubsalicylatesCarbamazepineCarbamazepine accelerates metabolism of Corticosteroids (reduced effect).CholestyramineColestipol (HCl)DicumarolFrusemide or FurosemideGentamicincoadministration may potentiate gentamicin nephrotoxicityIndacaterolconcomitant therapy may increase risk of hypokalemiamonitor closelyIpilimumabCorticosteroids interfere with the pharmacodynamic activity and efficacy of ipilimumabCorticosteroids (e.g hydrocortisone) or other immunosuppressant should be avoided before starting ipilimumab. However, these can be used after starting ipilimumab to treat immune related adverse reactions. LofexidineTheoretical potential for HYDROCORTISONE reducing the HYPOTENSIVE effect of LOFEXIDINE HYDROCHLORIDE. ModerateMephenytoinMethohexitone (Na)MetyrosineTheoretical potential for HYDROCORTISONE reducing the HYPOTENSIVE effect of METIROSINE. ModerateNatamycinConcurrent use may increase the toxicity, therefore concomitant use is contraindicated. NeostigmineOxandroloneThe concomitant administration of oxandrolone and adrenal cortical steroids may increase the edema in patients with edema. The mechanism and clinical significance are unknown. Closer monitoring may be appropriate, especially in patients with conditions that may be aggravated by fluid retention.MinorPentobarbitone (Na)PhenobarbitonePhenytoin (Na)PrimidonePromethazine (HCl)QuinidineRhubarbPotassium deficiency can be increased by concurrent use.RifampicinRotavirus vaccineThe administration of live, attenuated virus or bacterial vaccines during immunosuppressant or intense antineoplastic therapy may be associated with a risk of disseminated infection due to enhanced replication of vaccine virus or bacteria in the presence of diminished immune competence. Patients may be immunosuppressed if they have recently received Hydrocortisone.ModerateIn general, live virus or bacterial vaccines should not be used in patients receiving Hydrocortisone.Tacrine (HCl)Tice-BCGHydrocortisone may increase the risk of serious, life-threatening infections when given concurrently with Tice-BCG. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Increases Cortisol metabolites in urine

Drug should not be given to Paediatrics, Pregnant Mothers, Cardiac / Hypertensive Patients, patients suffering from Liver Malfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Inj, Oral Susp, Dental Paste, Cream, Oint Store Below 40°C. Do not Freeze. Protect from Sunlight. Suppositories Store at room temperature, Below 15°C or in refrigerator. Do not Freeze. Protect from Sunlight and Moisture. Tab Store at room temperature.

Hydrocortisone should be used with caution in patients with active tuberculosis infection of respiratory tract or in untreated fungal, bacterial or systemic viral infections. Corticosteroids should only be used systemically with great caution in the presence of congestive heart failure (CHF), recent myocardial infraction (MI), hypertension, diabetes mellitus, epilepsy, glaucoma, hypothyroidism, liver failure, osteoporosis, peptic ulceration or renal impairment. Children may be at increase risk of some adverse effects, corticosteroid causes growth retardation and prolonged use is rarely justified. Passive immunization is recommended to non-immune patients who do come in contact with chickenpox or measles. Live vaccine should not be given to patients receiving high dose systemic corticosteroid therapy nor for atleast 3 months afterwards, killed vaccine or toxoids may be given, although the response may be attenuated. During prolong treatment with corticosteroids, patients should be examined regularly, sodium intake may need to be reduced and calcium and potassium supplement may be necessary. Patient should carry cards given full details of their corticosteroid therapy. Avoid use during pregnancy. Use nasal steroids with caution until healing has occurred. Donot take Hydrocortisone if you are allergic to it. Donot exceed recommended dose. Avoid getting this medication in your eyes. Caution is required in children.