Hydralazine (HCl)

Hydralazine is antihypertensive agent. It acts as a vasodilator. It relaxes and expands blood vessels and lowers the blood pressure. It also function as antioxidant. It has been available for many years, though it was initially thought not to be particularly effective because tachyphylaxis to hypertensive effects developed rapidly. Now the benefits of combination therapy are recognized, and may be used more effectively particularly in severe hypertension.

Brands
HYDRALAZINE HYDRALAZINE
Adult Dose
Dose: 0.143 to 0.357 mg/kg
Single Dose: 0.25 (0.25)
Frequency: 6 hourly
Route: PO
Instructions: Initially for Several Weeks
Neonatal
Dose: 0.2 mg/kg
Single Dose: 0.2 (0.2)
Frequency: As recommended.
Route: Intra Muscular
Instructions: Initially for Once or repeated after 30 Minutes
Paedriatic
Dose: 0.1 to 0 mg/kg
Single Dose: 0.05 (0.05)
Frequency: As recommended.
Route: Intra Muscular
Instructions: Initially for Once or repeated after 30 Minutes
Characteristics
Hydralazine (HCl) also known as Apressinum, Apressinum. . It is of Synthetic origin and belongs to Phthalazine. It belongs to Vasodilators pharmacological group on the basis of mechanism of action and also classified in Antihypertensive Agents pharmacological group.The Molecular Weight of Hydralazine (HCl) is 196.60. Its pKa is 0.5, 7.3.
Contraindications
Hydralazine (HCl) is contraindicated in conditions like Angina,Rheumatic mitral valvular heart disease,Hypersensitivity.
Effects
The severe or irreversible adverse effects of Hydralazine (HCl), which give rise to further complications include Tachycardia, Lupus erythematosus, Hydralazine lupus, Peripheral neuritis, Tachycardia.The symptomatic adverse reactions produced by Hydralazine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Headache, Diarrhea, Palpitation, Impotence, Flushing, Tremor, Nausea and vomiting, Muscle cramps, Edema, Micturition, Chest pain, Lacrimation, Loss of appetite, angina pectoris.
Indications
Hydralazine (HCl) is primarily indicated in conditions like Benign gastric and duodenal ulcers, Heart failure, Hypertension, Hypertension with renal complications and hypertensive crisis (including during pregnancy), Hypertensive emergencies, Moderate to severe hypertension, Moderate to severe hypertension (adjunct), Primary pulmonary hypertension, Severe or recurrent duodenal and gastric ulcertion, and can also be given in adjunctive therapy as an alternative drug of choice in Heart failure (with long acting nitrate).
Interactions
Hydralazine (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholAlprostadilEnhanced hypotensive effects when alprostadil given with Hydralazine (HCl).CisplatinCoadministration increases the risk of peripheral neuropathy.ModerateClosely monitor for the symptoms of neuropathy such as burning, tingling, pain, or numbness in hands and feet. Either reduce the dose or discontinue in patients who develop peripheral neuropathy.Clonidine (HCl)DeflazacortDiazoxideEnhanced hypotensive effect when Diazoxide given with Hydralazine.DiazoxideDigoxinNicorandilConcurrent use can cause a drop in blood pressure, therefore you should tel your doctor know if you feel dizzy during concurrent use of these drugs. Oxprenolol (HCl)Propranolol (HCl)Tiaprofenic AcidHydralazines antihypertensive effect is decreased.Avoid concurrent use. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Serum test for SGOT, Glucose and Uric Acid Urine tests for Catecholamines
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store Below 30°C. Do not Freeze. Tab Store in a well closed container, Below 40°C. Protect from Sunlight.
Warnings
Hydralazine should be used with caution in patients with coronary artery disease, cerebrovascular disease, severe renal (kidney) damage. Monitor complete blood count at baseline & periodically during therapy. Take Hydralazine with meals or snacks. Avoid alcohol as it may worsen its side effects. Cautions should be taken if you ever had coronary artery disease or a heart attack. Donot stop this drug suddenly as it cause your blood pressure to become dangerously high.Drug induced lupus like syndrome Ou large doses &l long duration.
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