Human Insulin

Insulin is a small protein. It contains 51 amino acid arranged in two chains (A and B) joined together by disulfide linkage. Human Insulin is produced by semisynthetic and recombinant DNA techniques. In 1921, Banting and Best extracted insulin from the pancrease and demonstrated its therapeutic effects in diabetic dogs and human subjects. its appears to be as effective as conventional animal insulins, it appears to be considerably less immunogenic in diabetes patients than beef-pork insulins.


Adult Dose
Dose: 0.05 to 0.2 IU/ kg
Single Dose: 0.12 (0.125)
Frequency: 12 hourly
Route: IV
Instructions: Dose depends upon blood sugar level
Neonatal
Dose: 0.25 to 0.5 IU/kg
Single Dose: 0.38 (0.375)
Frequency: 24 hourly
Route: Subcutaneous
Instructions:
Paedriatic
Dose: 0.25 to 0.5 IU/kg
Single Dose: 0.38 (0.375)
Frequency: 24 hourly
Route: Subcutaneous
Instructions: -
Characteristics
Human Insulin also known as . . It is of Natural origin and belongs to Polypeptide. It belongs to Insulin agonist pharmacological group on the basis of mechanism of action and also classified in Antidiabetic Agent, Insulin pharmacological group.The Molecular Weight of Human Insulin is 5777.60.
Contraindications
Human Insulin
Effects
Human Insulin produces potentially life-threatening effects which include Hypoglycemia, Hypoglycemia, Hypoglycemia. which are responsible for the discontinuation of Human Insulin therapy.
Indications
Human Insulin is primarily indicated in conditions like Diabetes mellitus, Hyperkalaemia, Iddm.
Interactions
Human Insulin is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAdrenalineAlcoholAmitriptyline (HCl)AspirinCaptoprilACE inhibitors (e.g Captopril) possibly enhance hypoglycemic effect of insulin. Chlordiazepoxide (HCl)Chlorpromazine (HCl)Clonidine (HCl)CyclophosphamideDanazoldanzaol increase insulin resistancepatient should be carefully monitoredDiazoxideDiltiazem (HCl)DisopyramideFenfluramine (HCl)GestodeneGuanethidineIsoniazidLithiumLynoestrenolMebendazoleNadololNifedipineOctreotide (Acetate)Troglitazone These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to patients suffering from Kidney dysfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store at room temperature, Below 15°C or in refrigerator. Do not Freeze. Protect from Sunlight. Use within 2 years(at 4C) if refrigerated and within 1 month if kept at room temperature.
Warnings
its doses will vary among patients and should be determined by the healthcare provider familiar with the patient€™s metabolic needs, eating habits, and other lifestyle variablesThe dose of insulin lispro protamine when available in combination with insulin lispro (75/25 or 50/50 ratio) should be given within 15 minutes before a meal.
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