Alfentanil (HCl)

Alfentanil (HCl) is a potent (micro)u-receptor agonist opioid with a very rapid onset of action. Alfentanil (HCl) is a synthetic opioid derived from fentanyl. Alfentanil (HCl) is a narcotic analgesic (relieves pain with loss of consciousness). Alfentanil (HCl) is used as a primary anaesthetic (agent that causes loss of sensation) for the induction of anaestheia in general surgery and as a analgesic adjunct in the maintenance of anaesthesia with other drugs. Alfentanil (HCl) is not available in any combination preparation. Alfentanil (HCl) is administered intravenously.

Brands
Adult Dose
Dose: 1 ug/kg
Single Dose: 1 (1)
Frequency: As recommended.
Route: IV
Instructions: Maintenance per week, As Required
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to Propionanilide. It belongs to OPIATE agonist pharmacological group on the basis of mechanism of action and also classified in Analgesic-Narcotic pharmacological group.The Molecular Weight of Alfentanil (HCl) is 471.00. Its pKa is 6.5.
Contraindications
Alfentanil (HCl) is contraindicated in conditions like Hypovolaemia,Respiratory insufficiency.
Effects
Alfentanil (HCl) produces potentially life-threatening effects which include Apnea, Muscle rigidity, Respiratory depression, Bradycardia. which are responsible for the discontinuation of Alfentanil (HCl) therapy.The signs and symptoms that are produced after the acute overdosage of Alfentanil (HCl) include Hypotension, Pulmonary edema, Rhabdomyolysis.The symptomatic adverse reactions produced by Alfentanil (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting.
Indications
Alfentanil (HCl) is primarily indicated in conditions like Analgesia and suppression of respiratory activity, Analgesia especially during short operative procedure, Opioid anesthesia induction, Opioid anesthesia maintenance, Post-operative pain, and can also be given in adjunctive therapy as an alternative drug of choice in Sedation.
Interactions
Alfentanil (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementBuprenorphine (HCl)FluconazoleKetoconazoleKetoconazoleNalbuphine (HCl)PentazocineSuxamethonium (Cl)Vecuronium (Br)VORICONAZOLEmay increase the serum concentration of alfentanil by decreasing its metabolism. Monitor for increased anesthetic and respiratory depressant effects and consider using lower alfentanil doses or alternate anesthetic. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Liver Malfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
IV Inj, IV Inf. Store at room temperature.
Warnings
Alfentanil should be used with caution in patients with central nervous system (CNS) depression, convulsive disorder, ulcerative colitis, fever, recent gastrointestinal (GI) surgery, bradyarrhythmias, supraventricular tachycardia, pulmonary diseases. Patients should exercise caution while driving or performing tasks requiring alertness because it may produce drowsiness.
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