Heparin (Na) and Heparin (Cl)

'Heparin (Na) and Heparin (Cl) is anticoagulant agent. Heparin (Na) and Heparin (Cl) is a highly negatively charged heterogeneous mixture of sulfated mucopolysaccharide, varying in the molecular weights and composed of polymer of alternating derivatives of D-glucosamine and L-iduronic acid or D-glucuronic acid, having the property of prolonging the clotting time of blood. Heparin is the body''s natural anticoagulant. Heparin (Na) and Heparin (Cl) is usually obtained from the lungs, intestinal mucosa or other suitable tissue of domestic mammals used for food by man. Heparin is employed clinically in conditions in which a rapid reduction in the coagulation ability of blood is desired. Heparin calcium and heparin sodium are the calcium and sodium salts of active principles that compose heparin. Heparin calcium and sodium are administered intravenously or subcutaneously.'

Brands
CONTRACTUBEX HEPARIN ECAFAST HEPARIN HEPARIN HEPARIN HEPARIN EPSOCLAR HAEMASAL HAEMASAL PINE HEPARIN HEPARINOL HEPARINOL CARDIOPARIN CARDIOPARIN CARDIOPARIN MULTIPARIN
Adult Dose
Dose: 5000 IU
Single Dose: 5000 (5000)
Frequency: As recommended.
Route: IV
Instructions: For treatment of deep vein thrombosis.
Neonatal
Dose: 25 IU/kg.hr
Single Dose: 25 (25)
Frequency: As recommended.
Route: IV Infusion
Instructions: As Required
Paedriatic
Dose: 25 IU/kg.hr
Single Dose: 25 (25)
Frequency: As recommended.
Route: IV Infusion
Instructions: As Required
Characteristics
Heparinoids, Heparinoids are the derivatives of Heparin (Na) and Heparin (Cl). It is of Natural origin and belongs to Mucopolysaccharides. It belongs to Blood Coagulation pharmacological group on the basis of mechanism of action and also classified in Anticoagulants and Anti Acne pharmacological group.The Molecular Weight of Heparin (Na) and Heparin (Cl) is 16500.00. Its pKa is low.
Contraindications
Heparin (Na) and Heparin (Cl) is contraindicated in conditions like Subarachnoid haemorrhage,Renal failure,Haemostatic defect,Hepatic failure,Cerebral hemorrhage,Arterial thrombosis,Wounds,Abdominal bleeding.
Effects
The severe or irreversible adverse effects of Heparin (Na) and Heparin (Cl), which give rise to further complications include Osteoporosis, Skin necrosis, Hypoaldosteronism.Heparin (Na) and Heparin (Cl) produces potentially life-threatening effects which include Thrombocytopenia, Bleeding. which are responsible for the discontinuation of Heparin (Na) and Heparin (Cl) therapy.The signs and symptoms that are produced after the acute overdosage of Heparin (Na) and Heparin (Cl) include Bleeding.The symptomatic adverse reactions produced by Heparin (Na) and Heparin (Cl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Urticaria, Rhinitis, Conjunctivitis, Asthma, Cyanosis, Oppressive feelings, Angioedema, Anaphylactic shock, Tachypnea, Delayed-type hypersensitivity.
Indications
Heparin (Na) and Heparin (Cl) is primarily indicated in conditions like Analgesia, Angina, Consumptive thrombohemorrhagic disorders, Deep vein thrombosis, During pregnancy, Maintenance of light anaesthesia, Metastatic germ cell cancers (seminoma and teratoma), Myocardial infarction, Prophylaxis of thrombosis, Pulmonary embolism, Treatment of deep-vein thrombosis and pulmonary embolism.
Interactions
Heparin (Na) and Heparin (Cl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAbciximabAlcoholAlteplaseAprotininAprotininAspirinAspirin enhances anticoagulant effects of Heparin by interfering with platelet adhesion result in increased risk of bleeding.ModerateClose clinical and laboratory observation is recommended for bleeding complication.Desmopressin (Acetate)DexketoprofenDextranDihydroergotamine (Mesylate)DipyridamoleDopexamine (HCl)Doxorubicin (HCl)EpirubicinGlyceryl TrinitrateHyaluronidaseIchthammolIloprostKetorolac (Tromethamine)LypressinMezlocillinOzagrel SodiumWhen used with platelet anti-coagulant, thrombosis dissolutant or other anti-coagulants, hemorrhagic tendency can be increasedit should be used with extreme care. If necessary, the dose can be decreased. PentazocinePromethazine (HCl)Propylene GlycolSalicylic AcidSodium Tetradecyl SulphateStreptokinaseTenecteplaseHeparin (Na) and Heparin (Cl) may increase the risk of bleeding if administered prior to, during or after Tenecteplase therapy.UrokinaseVasopressinVortioxetineeither increases effects of the other by serotonin levelsmonitor closelyZinc OxideZinc Sulphate These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Thyroid Function TestPropranalol Estimations Benzodiazepine Estimations
Risks
Drug should not be given to Paediatrics, and Geriatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store at room temperature, Between 15°C-25°C. Do not Freeze. Protect from Sunlight.
Warnings
Heparin should be used with caution in presence of mild kidney or liver disease,patients of diabetes,hypertension,in women over 60 yrs.of age.If the coagulation test is prolonged or hemorrhages occur then discontinue the drug. Heparinoids should be used with caution in patients hypertension, stroke, hemorrhage, bleeding, thrombocytopenia associated with positive invitro test for antiplatelet antibody in presence of danaparoid.
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