Griseofulvin

Griseofulvin is antifungal agent produced by Pencillium griseofulvum. It acts as a fungistatic. It has been largely replaced by a newer antifungal medications such as itraconazole and terbinafine.


Adult Dose
Dose: 500 to 1000 mg
Single Dose: 750 (750)
Frequency: 24 hourly
Route: PO
Instructions:
Neonatal
Dose: 10 mg/kg
Single Dose: 10 (10)
Frequency: 24 hourly
Route: Oral
Instructions:
Paedriatic
Dose: 10 mg/kg
Single Dose: 10 (10)
Frequency: 24 hourly
Route: Oral
Instructions: -
Characteristics
Griseofulvin also known as Curling Factor. . It is of Natural origin and belongs to Benzofuran. It belongs to Antifungals pharmacological group.The Molecular Weight of Griseofulvin is 352.80.
Contraindications
Griseofulvin is contraindicated in conditions like Systemic lupus erythematosus,Porphyrias,Hepatic failure.
Effects
Griseofulvin produces potentially life-threatening effects which include Angioedema. which are responsible for the discontinuation of Griseofulvin therapy.The symptomatic adverse reactions produced by Griseofulvin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Diarrhea, Urticaria, Severe headache, Drug eruptions, Cholestasis, Leprosy.
Indications
'Griseofulvin is primarily indicated in conditions like Dermatophytic infections, Fungal infection, Parkinson''s disease.'
Interactions
Griseofulvin is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholAmorolfineAspirinGriseofulvin decreases the serum concentration of aspirin by interfering its absorptionMinorIf these drugs must be given together , staggered the dose and carefully monitor the level of salicylate.Bromocriptine (Mesylate)Cimetidine (HCl)DydrogesteroneEstradiol (Valerate)Estrogens ConjugatedEthinyloestradiolEthynodiol (Diacetate)Megestrol (Acetate)MeprobamateMesteroloneNorethisteronePhenobarbitonePhenobarbitoneWarfarin (Na)Griseofulvin may increase the metabolism, via CYP isoenzymes, of Warfarin. ModerateMonitor for decreased therapeutic effects of Warfarin if Griseofulvin is initiated/dose increased, or increased effects if Griseofulvin is discontinued/dose decreased. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Avoid alcoholic beverages while taking Griseofulvin unless doctor gives permission, drinking alcohol during treatment with this drug could result in a rapid heart rate and flushing of the skin. It should be used cautiously during pregnancy only if clearly needed. Griseofulvin may increase sensitivity to sunlight, so wear protective clothing and an appropriate sunscreen or avoid sun lamps.
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