Goserelin (Acetate)

Goserelin (Acetate) is anticancer agent, also called as antineoplastic drug. Goserelin (Acetate) is a synthetic peptide analoge of naturally occuring gonadotrophin releasing hormone. Goserelin (Acetate) is more potent than the natural hormone, has longer duration of action, and function as gonadotrophin releasing hormone agonist.

Brands
ZOLADEX
Adult Dose
Dose: 3.6 mg
Single Dose: 3.6 (3.6)
Frequency: As recommended.
Route: SC
Instructions: Every 28th day for 6 Months
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
. It is of Synthetic origin and belongs to Peptide. It belongs to LH-RH agonist pharmacological group on the basis of mechanism of action and also classified in Antineoplastic Agent, Miscellaneous pharmacological group.The Molecular Weight of Goserelin (Acetate) is 1269.40. Its pKa is 6.2.
Contraindications
Goserelin (Acetate)
Effects
The severe or irreversible adverse effects of Goserelin (Acetate), which give rise to further complications include Spinal cord compression, Ureteric obstruction.Goserelin (Acetate) produces potentially life-threatening effects which include Hypertestosteronemia, Elevated serum testosterone. which are responsible for the discontinuation of Goserelin (Acetate) therapy.The signs and symptoms that are produced after the acute overdosage of Goserelin (Acetate) include Elevated serum testosterone.The symptomatic adverse reactions produced by Goserelin (Acetate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Urticaria, Bone pain, Hot flushes, Anaphylaxis, Pruritis, Withdrwal bleeding.
Indications
Goserelin (Acetate) is primarily indicated in conditions like Advanced breast cancer( er+ve early breast cancer), Before surgery in women who have anaemia due to uterine fibroids, Breast cancer and prostate cancer, Endometrial thinning before intra-uterine surgery, Endometriosis, Pituitary desensitisation, Prostate cancer, Prostatic cancer, Uterine fibroids.
Interactions
No data regarding the interactions of Goserelin (Acetate) was found.
Interfrence
Elevations of SGPT and SGOT Gonadotrophin Test Elevation in ALT or AST
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store Below 15°C. Protect from Sunlight.
Warnings
Goserelin should be used with caution in patients with history especially of any undiagnosed vaginal bleeding, urination problems, spinal cord problems and of any drug allergies. It is not recommended for use during pregnancy or lactation.polycystic overy disease, diabetes, ureteric obstruction. pinal cordcompression in men.
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