Gonadorelin (HCl)

Gonadorelin (HCl) is the mono or dihydrochloride salt of gonadorelin which is a synthetic form of hypothalamic gonadotrophin-releasing hormone, structurally identical to the natural hormone. Gonadorelin (HCl) is used in the treatment of amenorrhea and infertility due to ovarian hormone deficiency.

Brands
Adult Dose
Dose: 0.357 to 1.429 ug/kg
Single Dose: 0.89 (0.893)
Frequency: As recommended.
Route: IV
Instructions: As Required
Neonatal
Dose: 12.5 ug/kg
Single Dose: 12 (12.5)
Frequency: As recommended.
Route: Intravenous
Instructions:
Paedriatic
Dose: Not licensed for used in children under 1 year.
Single Dose:
Frequency:
Route:
Instructions:
Characteristics
. It is of Synthetic origin and belongs to Peptide. It belongs to LH-RH agonist pharmacological group on the basis of mechanism of action and also classified in Diagnostic Aids pharmacological group.The Molecular Weight of Gonadorelin (HCl) is 1182.30.
Contraindications
Gonadorelin (HCl) is contraindicated in conditions like Genital bleeding,Ovarian failure.
Effects
Gonadorelin (HCl) produces potentially life-threatening effects which include Anaphylactic reactions. which are responsible for the discontinuation of Gonadorelin (HCl) therapy.The symptomatic adverse reactions produced by Gonadorelin (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Pruritus, Hypersensitivity reactions, Skin rash, Flushing, Thrombophlebitis, Light headedness, Septicemia, Local swelling, Abdominal discomfort, Irritation at injection site, Increase menstrual bleeding.
Indications
Gonadorelin (HCl) is primarily indicated in conditions like Amenorrhoea, Infertility, Precocious puberty, Prostate cancer.
Interactions
No data regarding the interactions of Gonadorelin (HCl) was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store in a well closed container. Refrigeration is recommended. Protect from Sunlight.
Warnings
It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Gonadorelin (HCl) is administered to a nursing woman. Safety and effectiveness in pediatric patients have not been established.pipuitary adenoma, pregnancy, lactation DIN. Thyroid & adrenal should be evaluated.
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