DAONIL DAONIL GLIMET GLIMET GLIMET GLAONIL SEMI GLICON SEMI METCON METCON GLICON METCON PLUS GLIFORMIN GLABINOL MACLAMIDE DIAMIN GLANORM GLUCOVANCE GLUCOVANCE GLUCOVANCE GLIFEN GLUCOMET PLUS GLUCOMET PHARMIDE EUGLUCON BENIL GLIBEN PLIGLIBEN GLIBOMET DIABETA GLIFOR GLUKIL GLUCOTAB DICON METAMIDE PLUS DESUGAR DIAZET BENCLAMIDE BEMIDE GLIMME GLUCOBAN IBENESE GLIBETIDE DIABINIL GLICAM BENCLAM JACLAMIDE GLICARE GLICARE

Dose: 2.5 mg
Single Dose: 2.5 (2.5)
Frequency: 24 hourly
Route: PO
Instructions: Dose may be increased by 2.5 mg.

Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group

Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group

Glibenclamide also known as Glyburide. . It is of Synthetic origin and belongs to Sulphonylurea. It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action and also classified in Drugs Afecting Glucose Metabolism and Antidiabetic Agent, Sulfonylurea pharmacological group.The Molecular Weight of Glibenclamide is 494.00. Its pKa is 5.3.

Glibenclamide is contraindicated in conditions like Renal failure,Liver diseases,Diabetic coma,Impaired renal function,Insulin dependent diabetes mellitus.

The severe or irreversible adverse effects of Glibenclamide, which give rise to further complications include Thrombocytopenia, Cholestatic jaundice, Aplastic anemia, Hemolytic anemia, Cholestatic jaundice, Aplastic anemia, Hemolytic anemia, Leucopenia, Agranulocytosis, Pancytopenia, Hemolytic anemia, Aplastic anemia.Glibenclamide produces potentially life-threatening effects which include Hypersensitivity reactions, Renal failure, Hypoglycemia, Hypoglycemia, Hypoglycemia, Pneumonia. which are responsible for the discontinuation of Glibenclamide therapy.The signs and symptoms that are produced after the acute overdosage of Glibenclamide include Coma, Hypoglycemia, Cerebral damage.The symptomatic adverse reactions produced by Glibenclamide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, GI upset, Heart burn, Allergic skin reactions, Hepatitis, Hypoglycemia.

Glibenclamide is primarily indicated in conditions like Non-insulin dependent diabetes mellitus, Softening and dilatation of cervix before mechanical cervical dilatation.

Glibenclamide is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholBosentanPlasma concentration of both drugs reduced when Bosentan given with Glibenclamide; avoid concomitant use.MajorDiazoxideDiazoxide antagonises hypoglycaemic effect of antidiabetics.LinagliptinLinagliptin increases AUC and Cmax of Glibencamide by 14%LornoxicamMay increase the hypoglycaemic effect of sulphonylurea.Metformin (HCl)MethylprednisoloneSteroids (e.g Methylprednisolone) induced hyperglycemia may partially antagonize the effect of hypoglycemic drugs (e.g Glibenclaimide)Propranolol (HCl)Tincture MyrrhTincture Myrrh may increase the level of suger in blood if taking myrrh by mouth & may interfere with the effectiveness of medications used for the treatment of diabetes.Warfarin (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Drug should not be given to Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Store Below 20°C. Tab Store in a well closed container, Below 40°C.

During treatment with glibenclamide, compliance to diet and regular tablet intake are of utmost importance to preserve the efficacy of treatment and to avoid unwanted changes in the blood sugar levels. Hypoglycemic reactions may provoked by overdosage of glibenclamide, interacting drugs , dietary errors (omitting meals), the signs of it being headache, irritability, restlessness, profuse sweating, insomnia, tremor, impairment of performence and alertness, such hupoglycemic episodes are nearly always promptly relieved by the intake of sugar.