Gemeprost

Gemeprost is a synthetic prostaglandin. Gemeprost is used to to prepare the uterus for surgical termination of pregnancy.


Brands
Adult Dose
Dose: 0.014 mg/kg
Single Dose: 0.014 (0.014)
Frequency: As recommended.
Route: Intra Vaginal
Instructions: As Required, prior to surgery
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
. It is of Synthetic origin and belongs to Oxocyclopentylheptenoate. It belongs to PGF-II alpha-agonist pharmacological group on the basis of mechanism of action and also classified in Abortifacients pharmacological group.The Molecular Weight of Gemeprost is 394.00.
Contraindications
Gemeprost is contraindicated in conditions like Asthma,Bronchospasm.
Effects
Gemeprost produces potentially life-threatening effects which include Myocardial infarction, Severe hypertension, Coronary artery spasm. which are responsible for the discontinuation of Gemeprost therapy.The symptomatic adverse reactions produced by Gemeprost are more or less tolerable and if they become severe, they can be treated symptomatically, these include Fatigue, Diarrhea, Constipation, Abdominal pain, Rashes, Dyspepsia, GI symptoms, Eczema, dyspepsia, Vaginal bleeding, Mild uterine pain.
Indications
Gemeprost is primarily indicated in conditions like Abortion, Second trimester abortion, Second trimester intra-uterine death, Transcervical operative procedures in first trimester.
Interactions
Gemeprost is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementMifepristoneOxytocin These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
No significant effect were recorded on Alkaline Phosphate or on hemosfatic system.
Risks
Drug should not be given to patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Pessary Store Below -15°C.
Warnings
Gemeprost should be used with caution in patients with obstructive air way disease, cardiovascular disease, raised intraocular pressure. Avoid use in women with history of uterine surgery. Cervittis or vaginitis. Pulse and Blood pressure should be monitored.
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