CYMEVENE CYMEVENE GANVIR GANVIR GANTOVIR

Dose: 5 to 5 mg/kg
Single Dose: 5 (5)
Frequency: 12 hourly
Route: IV
Instructions: Treatment (For 14-21 days)

Dose: Safety not established
Single Dose:
Frequency:
Route:
Instructions:

Dose: Safety not established
Single Dose:
Frequency:
Route:
Instructions:

Ganciclovir (Na) also known as Gamciclovir Sodique, Gamciclovir Sodique. . It is of Synthetic origin and belongs to Guanine Salt. It belongs to DNA polymerase inhibitor pharmacological group on the basis of mechanism of action and also classified in Antiviral Agents pharmacological group.The Molecular Weight of Ganciclovir (Na) is 277.00. It is weakly alkaline drug.

Ganciclovir (Na) is contraindicated in conditions like Neutropenia,Thrombocytopenia,Pregnancy,Hypersensitivity to the drug,Breast feeding,Severe infections, see instruction.

The severe or irreversible adverse effects of Ganciclovir (Na), which give rise to further complications include Gonadal toxicity, Renal impairment.Ganciclovir (Na) produces potentially life-threatening effects which include Thrombocytopenia, Neutropenia. which are responsible for the discontinuation of Ganciclovir (Na) therapy.The signs and symptoms that are produced after the acute overdosage of Ganciclovir (Na) include Neutropenia.The symptomatic adverse reactions produced by Ganciclovir (Na) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Diarrhea, Fever, Rashes, Confusion, Local pain, Phlebitis, Nausea and vomiting, Seizures and convulsions, Tingling, Abnormal LFT, Anemia, Eosinophilia, Abnormal mentation, Burning sensation, Confusion, Abnormal LFT.

Ganciclovir (Na) is primarily indicated in conditions like Cytomegalovirus infection (risk of relapse or retinitis), Cytomegalovirus infections, Local infiltration, Prophylaxis in bone marrow transplant recipient.

Ganciclovir (Na) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAmphotericin BAtovaquoneImipenemProbenecidRituximabGanciclovir (Na) may increase the risk and severity of hematologic toxicity due to additive pharmacodynamic effects. ModerateTacrolimusTenofovir DisoproxilGanciclovir (Na) may also increase serum concentrations of tenofovir.TrimethoprimZidovudine These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Caps Store in a well closed container, Below 40°C. Protect from Sunlight. Inj (reconstituted soln) Store at room temperature. Refrigeration and Freezing is not recommended. Use within 12 hrs if kept at room temperature. IV Inf Store in refrigerator. Do not Freeze. Use within 24 hrs if kept at room temperature.

Close monitoring of full blood count (severe detrioration may require correction or possibly treatment interruption); history of cytopenia; low platelet count; potential carcinogen and teratogen; renal impairment; radiotherapy; ensure adequate hydration during IV- adminstration; vesicant---- infuse into vein with adequate flow preferably using plastic cannula; children (possible risk of long-term carcinogenic or reproductive toxicity not for neonatal or congenital CMV diseaese). Avoid contacting the eyes, skin or mucous membranes with the contents of the capsule, if contact occurs, wash with plenty of soap and water, thoroughly rinse eyes with plain water.