Fusidic Acid

Fusidic Acid is a steroid antibiotic. Fusidic Acid is used to treat the infection caused by penicillin resistant staphylococci.


Adult Dose
Dose: 0.5 mg
Single Dose: 0.5 (0.5)
Frequency: 12 hourly
Route: Ophthalmic
Instructions: -
Neonatal
Dose: 12.5 mg/kg
Single Dose: 12 (12.5)
Frequency: 8 hourly
Route: Oral
Instructions:
Paedriatic
Dose: 1%
Single Dose: 1 (1)
Frequency: 12 hourly
Route: Opthalmic
Instructions: For Paeds of all ages
Characteristics
Fusidic Acid also known as Sodium fusidate. . It is of Semi Synthetic origin and belongs to Fusidane. It belongs to Antibacterial (Proetin synthesis inhibitor) pharmacological group on the basis of mechanism of action and also classified in Antibiotics pharmacological group.The Molecular Weight of Fusidic Acid is 525.70. Its pKa is 5.35.
Contraindications
Fusidic Acid is contraindicated in conditions like Hepatic failure,Hypersensitivity.
Effects
The severe or irreversible adverse effects of Fusidic Acid, which give rise to further complications include Jaundice, Jaundice, Cholestasis, Hemolysis, Hyperbilirubinemia.The symptomatic adverse reactions produced by Fusidic Acid are more or less tolerable and if they become severe, they can be treated symptomatically, these include Vomiting, Diarrhea, Rashes, Pruritus, GI symptoms, Epigastric pain.
Indications
Fusidic Acid is primarily indicated in conditions like Bone and joint infection, Cystic fibrosis, Endocarditis, Food allergy, Muscle relaxation (rapid onset, short duration), Osteomyelitis, Pneumonia, Septicaemia, Skin infections, Small cell carcinoma, Soft tissue infections.
Interactions
No data regarding the interactions of Fusidic Acid was found.
Interfrence
Measurement of Bile Acids in serum by enzymatic assay Fluoromet ric Tests for cortisol in urine and plasma
Risks
Drug should not be given to Pregnant Mothers, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Eye Oint Store in a well closed container, at room temperature, Below 25°C.
Warnings
Use of topical preparation near the eyes should be avoided because of potential conjunctival irritation. Parentrally the drug should be infused slowly to decrease to decrease the incidence of thrombophlebitis and vasospam. Oral administration should be instituted as soon as possible. Long term topical theorapy should beavoided particularly is infants & children.
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