Albendazole

Albendazole is a broad spectrum antiparasitic agent, developed as a veterinary anthelmintic and was first approved for humun use in 1982. Albendazole is a benzimidazole carbamate. Chemically Albendazole is identified as [5-(propylthio)-1H-benzimidazol-2y] carbamic acid methyl ester. Albendazole is effective against pin worm infection, ascariasis, trichuriasis and infection with both hookworm species. Albendazole is administerd orally.


Adult Dose
Dose: 400 mg
Single Dose: 400 (400)
Frequency: As recommended.
Route: PO
Instructions: Single dose (once) or as required.
Neonatal
Paedriatic
Dose: 40 mg/kg
Single Dose: 40 (40)
Frequency: 24 hourly
Route: Oral
Instructions: For 3 Days
Characteristics
. It is of Synthetic origin and belongs to Benzimidazole. It belongs to Fumarate reductase inhibitor pharmacological group on the basis of mechanism of action and also classified in Anthelmintics pharmacological group.The Molecular Weight of Albendazole is 265.30.
Contraindications
Albendazole is contraindicated in conditions like Hypersensitivity to the drug.
Effects
The severe or irreversible adverse effects of Albendazole, which give rise to further complications include Reversible neutropenia.The signs and symptoms that are produced after the acute overdosage of Albendazole include Vomiting, Tachycardia, Diarrhea, Respiratory distress.The symptomatic adverse reactions produced by Albendazole are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Vomiting, Diarrhea, Abdominal pain, Reversible alopecia.
Indications
Albendazole is primarily indicated in conditions like Ascariasis, Capillariasis, Enterobiasis, Giardiasis, Hook worm infection, Hydatid disease, Lymphatic filariasis, Microsporidiosis, Neurocysticercosis, Opisthorchis, Pin worm infection, Strongyloidiasis, Tapeworm infection, Thread-worm infection.
Interactions
Albendazole is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCarbamazepineCimetidine (HCl)DexamethasonePhenobarbital SodiumPhenytoin (Na)Praziquantel These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab, Susp Store in a well closed container, Below 40°C. Protect from Sunlight.
Warnings
Albendazole should be used with extreme caution in hepatic disease, breast-feeding and during pregnancy.
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