Foscarnet (Na)

Foscarnet (Na) is antiviral agent, is an inorganic pyrophosphate compound. Foscarnet (Na) is active against herpes simplex virus, vericella zoster virus, cytomegalovirus, and HIV. Foscarnet (Na) is approved for the treatment of cytomegalic retinitis in immuno compromised HIV patient, especially if the infection is resistant to ganciclovir.

Brands
Adult Dose
Dose: 0.66 mg/kg.min
Single Dose: 0.66 (0.66)
Frequency: As recommended.
Route: IV Inf
Instructions: For 30 Minutes, Followed by Maint. As Required
Neonatal
Paedriatic
Characteristics
Foscarnet (Na) also known as Phosphonatoformate Trisodium. . It is of Synthetic origin and belongs to Phosphonformate. It belongs to DNA polymerase inhibitor pharmacological group on the basis of mechanism of action and also classified in Antiviral Agents pharmacological group.The Molecular Weight of Foscarnet (Na) is 300.00. Its pKa is 7.27.
Contraindications
Foscarnet (Na) is contraindicated in conditions like Renal diseases,Pregnancy,Breast feeding.
Effects
The severe or irreversible adverse effects of Foscarnet (Na), which give rise to further complications include Thrombophlebitis, Headache.Foscarnet (Na) produces potentially life-threatening effects which include Nephrotoxicity, Acute Renal Failure, Bilateral loin pain, Prophylactic hydration, Tenderness. which are responsible for the discontinuation of Foscarnet (Na) therapy.The signs and symptoms that are produced after the acute overdosage of Foscarnet (Na) include Hallucinations, Irritability, Anxiety.The symptomatic adverse reactions produced by Foscarnet (Na) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Thrombophlebitis.
Indications
Foscarnet (Na) is primarily indicated in conditions like Cytomegalovirus infections, Cytomegalovirus retinitis in aids patients, Herpes simplex infections, HIV infection, Mucocutaneous herpes simplex infection, Viral infection.
Interactions
Foscarnet (Na) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAmphotericin BCyclosporin AGentamicinPentamidinePentamidineVORICONAZOLEAdditive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation Zalcitabine These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Elevation in ALT or AST
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
IV inf Store at room temperature. Do not Freeze.
Warnings
Foscarnet should be used with caution in patients with any pre-existing liver disease, kidney disease, heart disease, history of seizure disorder or any allergies. This medication should be used only if clearly needed during pregnancy.
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