KUNYRIN KUNYRIN KUNYRIN LEUCOVORIN LEUCOVORIN RESCUVOLIN RESCUVOLIN VIDAYLIN-T FERRUM FA FERVIGOR LEUCOVORIN CA LACHEMA MALTIRON F CLOMVIT-F LEUCODIX

Dose: 120 mg
Single Dose: 120 (120)
Frequency: As recommended.
Route: IV,IM
Instructions: In div.doses over 12-24 hrs.

. It is of Synthetic origin and belongs to water soluble vitamin. It belongs to Hematological Agents and Antidotes pharmacological group.The Molecular Weight of Folinic Acid is 473.40. Its pKa is 3.1, 4.8, 10.4.

Folinic Acid is contraindicated in conditions like Pernicious anaemia,Vitamin B12 deficiency.

The severe or irreversible adverse effects of Folinic Acid, which give rise to further complications include Nausea, Vomiting, Alopecia, Skin rashes, Neurological complications, Severe diarrhea.Folinic Acid produces potentially life-threatening effects which include Myelosuppression, Diarrhea, Allergic sensitization, Fatal anaphylaxis, Mucositis, Bloody rhinorrhea. which are responsible for the discontinuation of Folinic Acid therapy.The symptomatic adverse reactions produced by Folinic Acid are more or less tolerable and if they become severe, they can be treated symptomatically, these include Pyrexia.

Folinic Acid is primarily indicated in conditions like 5-fu therapy, As an antidote to methotrexate, Folate deficiency, Gastric acid reduction (surgical procedures), Methotrexate therapy, Prophylaxis of acid aspiration in obstetric patients, Suspected methotrexate overdosage.

Folinic Acid is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementFluorouracilMethotrexate These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Tab, Inj Store Below 40°C. Protect from Sunlight and Heat.

Caution is advised in patients who may have folate dependant tumor. Folinic acid should not be given alone or in conjunction with inadequate amount of vitamin B12 for the treatment of undiagnosed megaloblastic anaemia. Leucovorin should not be used in case of pernicious anemia secondary to vitamin B12 deficiency because the drug alleviates the hematological effects of B12 deficiency while allowing the neurological complications to continue. The drug can only be used during pregnancy when the potential risk to the fetus over- weigh against the potential benefits to the mother.