Flutamide

Flutamide is anticancer drug, also called as antineoplastic agent. Flutamide is used in the treatment of prostate cancer. Flutamide is used in combination with other anti-cancer drugs to obtain most excellent therapeutic effects and to reduce the side effects or toxicities.

Brands
FLUTAMIDA GADOR FLUTEN ELBAT
Adult Dose
Dose: 250 mg
Single Dose: 250 (250)
Frequency: 8 hourly
Route: PO
Instructions:
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
. It is of Synthetic origin and belongs to Toluidide. It belongs to Androgen antagonist pharmacological group on the basis of mechanism of action and also classified in Prostatic Hyperplasia pharmacological group.The Molecular Weight of Flutamide is 276.20.
Contraindications
Flutamide
Effects
The severe or irreversible adverse effects of Flutamide, which give rise to further complications include Hepatic damage, Cholestatic jaundice, Hepatic necrosis, Hepatic encephalopathy, Gynacomastia, Breast tenderness.Flutamide produces potentially life-threatening effects which include Hepatic injury. which are responsible for the discontinuation of Flutamide therapy.The symptomatic adverse reactions produced by Flutamide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Diarrhea.
Indications
Flutamide is primarily indicated in conditions like Advanced prostate cancer, Benign prostatic hyperplasia, Oncology, Prostatic cancer.
Interactions
Flutamide is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementLeuprolide (Acetate)VORICONAZOLEVoriconazole may increase the serum concentration of flutamide by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of flutamide if voriconazole is initiated, discontinued or dose changed.Warfarin (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Caps Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Flutamide must be given under close medical supervision. This drug is not recommended for use in children. This drug is not recommended for use in pregnant or nursing women.
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