Flupenthixol (HCl and Decanoate)

Flupenthixol (HCl and Decanoate) is a tranquillizer. Flupenthixol (HCl and Decanoate) is used in depressive and anxiety states associated with inertia and apathy.


Adult Dose
Dose: 1 to 2 mg
Single Dose: 1.5 (1.5)
Frequency: 24 hourly
Route: PO
Instructions: For depression Max dose 3 mg.
Neonatal
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
belongs to Thioxanthene. It belongs to D2 antagonist pharmacological group on the basis of mechanism of action and also classified in Psychotherapeutic Drugs and Antidepressant Tricyclic pharmacological group.The Molecular Weight of Flupenthixol (HCl and Decanoate) is 507.40. Its pKa is 3.4.
Contraindications
Flupenthixol (HCl and Decanoate) is contraindicated in conditions like Parkinsonism,Coma.
Effects
Flupenthixol (HCl and Decanoate) produces potentially life-threatening effects which include Tachycardia, Cardiac arrhythmias, Neuroleptic Malignant Syndrome, B.P instability. which are responsible for the discontinuation of Flupenthixol (HCl and Decanoate) therapy.The signs and symptoms that are produced after the acute overdosage of Flupenthixol (HCl and Decanoate) include Convulsions, Coma, Hyperthermia, Shock, Somnolence.The symptomatic adverse reactions produced by Flupenthixol (HCl and Decanoate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dry mouth, Weight gain, Loss of libido, Tremor, Menstrual irregularity, Muscle rigidity, Transient insomnia, Erectile disturbance, Breast engorgement.
Indications
Flupenthixol (HCl and Decanoate) is primarily indicated in conditions like Depression, Depressive illness, Enhance permeation of SC or IM inj, Muscle spasm of varied aeitology, Pain, Personality disorder, Post-operative nausea and vomiting, Psychosis, Relief of discomfort in mild UTIs, Schizophrenia.
Interactions
Flupenthixol (HCl and Decanoate) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholGuanethidineLevodopaLevodopaMetoclopramide (HCl)ProchlorperazineVORICONAZOLEAdditive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store Below 25°C. Protect from Sunlight. Tab Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Flupenthixol is not recommended in state of excitement or overactivity,including mania.
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