Flumazenil

Flumazenil is a 1,4- benzodiazepine derivative. Flumazenil is the only benzodiazepine receptor antagonist available for clinical use at present. Flumazenil is approved for use in reversing the sedative effects of certain drugs (benzodiazipines). Flumazenil is used to counteract effects of benzodiazipines overdose. Flumazenil is administered intravenously.

Brands
ANEXATE
Adult Dose
Dose: 200 ug
Single Dose: 200 (200)
Frequency: As recommended.
Route: IV
Instructions: Load for 15 Seconds
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to Benzodiazepine. It belongs to Chloride Channel Potentiater antagonist pharmacological group on the basis of mechanism of action and also classified in Antidotes pharmacological group.The Molecular Weight of Flumazenil is 303.30. Its pKa is 1.7.
Contraindications
Flumazenil is contraindicated in conditions like Epilepsy,Neuromuscular blockade.
Effects
The severe or irreversible adverse effects of Flumazenil, which give rise to further complications include Cardiac arrhythmias, Cardiac arrhythmias.Flumazenil produces potentially life-threatening effects which include Raised intracranial pressure. which are responsible for the discontinuation of Flumazenil therapy.The symptomatic adverse reactions produced by Flumazenil are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Anxiety, Confusion, Flushing, Agitation, Facial erythema, Resedation, Confusion, dizziness.
Indications
Flumazenil is primarily indicated in conditions like Poisoning of benzodiazepine, Reversal of sedative effects of benzodiazepines in anaesthetic, Unconciousness.
Interactions
No data regarding the interactions of Flumazenil was found.
Interfrence
None well documented
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj
Warnings
Flumazenil should be used with caution in patients with history of seizures, panic attacks, alcohol or drug dependency, breathing disorders, heart disease, liver disease, head injury or if have any allergy. This drug should be used only if clearly needed during pregnancy or lactation. This drug is not recommended for use in children.
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