Flucytosine

Flucytosine is antifungal agent. Flucytosine is fluorinated pyrimidine. its spectrum of activity is restricted to some Candida species and the dematiaceous mold. It was discovered in 1957 during a search for novel anticancerous agents. While devoid of anticancer properties, it became apparent that it was a potent antifungal agent. Flucytosine is a water soluble pyrimidine analog that is related to the chemotherapeutic agent fluorouracil. Flucytosine is administered orally.

Brands
Adult Dose
Dose: 1.25 mg/kg.min
Single Dose: 1.2 (1.25)
Frequency: 6 hourly
Route: IV Inf
Instructions: For 20-40 Minutes
Neonatal
Dose: 0.833 to 1.66 mg/kg.min
Single Dose: 1.2 (1.2465)
Frequency: 6 hourly
Route: IV Infusion
Instructions: For 30 Minutes
Paedriatic
Dose: 0.833 to 1.66 mg/kg.min
Single Dose: 1.2 (1.2465)
Frequency: 6 hourly
Route: IV Infusion
Instructions: For 30 Minutes
Characteristics
. It is of Synthetic origin and belongs to Flurinated Pyrimidine. It belongs to Antifungals pharmacological group.The Molecular Weight of Flucytosine is 129.10. Its pKa is 2.9, 10.7.
Contraindications
Flucytosine
Effects
The severe or irreversible adverse effects of Flucytosine, which give rise to further complications include Hypokalemia, Hepatic necrosis, Elevated alkaline phosphatase concentration, Deaths, Elevated transaminases, Disturbed liver function, Elevated alkaline phosphatase concentration.Flucytosine produces potentially life-threatening effects which include Thrombocytopenia, Leucopenia, Bone marrow toxicity, Death. which are responsible for the discontinuation of Flucytosine therapy.The symptomatic adverse reactions produced by Flucytosine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Diarrhea, Skin rashes, Sedation, Nausea and vomiting, Convulsions, Skin rashes.
Indications
Flucytosine is primarily indicated in conditions like Candidosis, Cryptococcosis, Meningitis, Obsessive-compulsive disorders, Torulopsosis, and can also be given in adjunctive therapy as an alternative drug of choice in Osteoporosis in men, Suppression of supraventricular tachycardias and ventricular arrhythmias.
Interactions
Flucytosine is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAmphotericin BAmphotericin reduces renal excretion and increases cellular uptake of Flucytosine (toxicity possibly increased). Amphotericin BCytarabine (HCl)Cytarabine (HCl) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Falsely elevated levels of Serum Creatinine by creatinine iminohydrolase method.
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Geriatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Store Between 15°C-25°C. Caps, Inj Store Below 40°C. Protect from Sunlight, Moisture and Heat.
Warnings
Flucytosine should be used only if clearly needed during pregnancy. It should be used with caution in patients with any pre-existing liver disease, kidney disease, bone marrow disorders or any allergy. Blood count should be mointered during therapy.
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