ACYCLOVIR ACLOVA ACLOVA ACYLEX ACYLEX ACYLEX ACYLEX ACYLEX ZOVIRAX ZOVIRAX ZOVIRAX ZOVIRAX ZOVIRAX CYCLOZ CYCLOZ CYCLOZ CYCLOZ CYCLOZ CYCLOZ CYCLOZ SANTOVIR SANTOVIR SANTOVIR SUPRAVIRAN SUPRAVIRAN SUPRAVIRAN SUPRAVIRAN SUPRAVIRAN HERPESIN ZACLOVIR ZACLOVIR ACYCLOVIR LOVIR VIRUSTAL VIRUSTAL VIRUSTAL VIRUSTAL VIRUX ELOVIR ACYROVIN OPHTH-CYCLOVIR ZORAXIN ZORAXIN ZORAXIN ZORAXIN ZORAXIN ZORAXIN ACICLOVIR ADEOWIN MEDIRAX CLOVIREX CLOVIREX CLOVIREX TOPICAL VIRUCID VIRUCID ACEFAS VIVER CLOVIR CLOVIR CYCLOR CYCLOR HERPIRID KLOVIR VIRACYL VIROCIL VIROCIL VIROLITE VIRQ ZANCOVIR ACYWEL DFOVIR

Dose: 3%
Single Dose: 3 (3)
Frequency: 4 hourly
Route: Ophthalmic
Instructions: As Required

Dose: 0 to 20 mg/Kg
Single Dose: 10 (10)
Frequency: 3 hourly
Route: For herpes simplex for 14 days and 21 days if CNS involvement. (For neonate and infant the age of upto 3 months)
Instructions:

Dose: 10 to 20 mg/kg
Single Dose: 15 (15)
Frequency: 3 hourly
Route: IV Infusion
Instructions: For months to 12 years.

Acyclovir also known as Acyloguanosine, Acyloguanosine, Acyloguanosine. . It is of Synthetic origin and belongs to Guanine. It belongs to DNA polymerase inhibitor pharmacological group on the basis of mechanism of action and also classified in Antiviral Agents pharmacological group.The Molecular Weight of Acyclovir is 225.00. Its pKa is 2.27, 9.25.

Acyclovir is contraindicated in conditions like Hypersensitivity.

The severe or irreversible adverse effects of Acyclovir, which give rise to further complications include Rises in blood urea and creatinine, Encephalopathy, Seizures, Acute renal failure, Renal tubular obstruction.Acyclovir produces potentially life-threatening effects which include Coma. which are responsible for the discontinuation of Acyclovir therapy.The symptomatic adverse reactions produced by Acyclovir are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Vomiting, Anorexia, Severe local inflammatory reactions, Tremors, Abdominal pain, Skin rashes, Confusion, Erythema, Lethargy, Itching, Hallucination, Malaise, Elevation of liver enzymes, Contact dermatitis, Agitation, Stinging on application, Crystalluria, Transient burning, Reaction at injection site, Confusion, Skin rashes.

Acyclovir is primarily indicated in conditions like Cytomegalovirus infection prophylaxis, Encephalitis, Herpes simplex, Herpes simplex (in immunocompromised patients), Herpes simplex infection of mucous membrane, Herpes simplex infection prophylaxis, Herpes simplex keratitis, Prophylaxis of herpes simplex, Severe initial genital herpes, Simplex encephalitis, Treatment of herpes simplex, Varicella and herpes zoster, Varicella zoster infections, Varicella-zoster, Varicella-zoster (chickenpox-shingles), Viral conjunctivitis, and can also be given in adjunctive therapy as an alternative drug of choice in Herpes simplex (prevention of recurrence), Prevention of recurrence of herpes simplex, Treatment of herpes simplex (immunocompromised patients).

Acyclovir is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAdefovir DipivoxilInterferon AlphaPhenytoin (Na)ProbenecidTenofovir DisoproxilAcyclovir may also increase serum concentrations of tenofovir.Zidovudine These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and Geriatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Inj (reconstituted soln) Store at room temperature. Use within 24 hrs if kept at room temperature. Tab, Caps, Oral Susp, Skin Oint Store in a well closed container, at room temperature, Between 15°C-25°C. Protect from Sunlight and Moisture.

This medication should be used with caution during pregnancy and lactation. Topical preparation (e.g cream) is not recommended for application to mucous membranes, particular care should be taken to avoid accidental introduction into the eyes.