Fenoprofen

Fenoprofen is NSAID (non-steroidal anti-inflammatory drug). Fenoprofen is a propionic acid derivative.Fenoprofen is used to relieve pain and to reduce fever and inflammation or swelling. Fenoprofen is used to treat pain, swelling and stiffness associated with arthritis. Fenoprofen is also used to treat headaches, dental pain and athletic injuries.


Brands
Adult Dose
Dose: 5.714 mg/kg
Single Dose: 5.7 (5.714)
Frequency: 24 hourly
Route: PO
Instructions: As Required
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
Fenoprofen also known as Fenopron, Fenopron, Fenopron, Fenopron, Fenopron, Fenopron. . It is of Synthetic origin and belongs to Propionic Acid Derivative. It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action and also classified in Analgesics and Anti-inflammatory Agents pharmacological group.The Molecular Weight of Fenoprofen is 558.60. Its pKa is 4.5.
Contraindications
Fenoprofen is contraindicated in conditions like Peptic ulcer,Renal failure.
Effects
The severe or irreversible adverse effects of Fenoprofen, which give rise to further complications include Renal damage, Thrombocytopenia, Allergic reactions, Bronchospasm, Stevens johnson syndrome, Bronchospasm, Stevens johnson syndrome, Angioedema, Angioedema, Pancytopenia, Papillary necrosis, Glomerular toxicity, Allergic nephritis.Fenoprofen produces potentially life-threatening effects which include GI bleeding, GI irritation, Dyspepsia, Peptic ulceration, Gastric hemorrhage, Hematuria, Proteinuria. which are responsible for the discontinuation of Fenoprofen therapy.The signs and symptoms that are produced after the acute overdosage of Fenoprofen include Hematuria, Headache, Proteinuria, Low abdominal pain, Tinnitus.The symptomatic adverse reactions produced by Fenoprofen are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Diarrhea, Constipation, Tinnitus, Sleep disturbancesX, Blurred vision, Peripheral edema, Termors, Confusion, Dysuria, Nausea and vomiting, Deafness, Ambylopia, Buccal ulceration, Cystitis, Increased intracranial pressure, Confusion, dizziness.
Indications
Fenoprofen is primarily indicated in conditions like Fever, Mild to moderate pain, Nausea and vomiting (palliative care), Osteoarthritis, Pain, Rheumatoid arthritis.
Interactions
Fenoprofen is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholCyclosporin ANateglinideConcurrent use may potentiate the hypoglycemic action of Nateglinide.Phenylbutazone Phenytoin (Na)Warfarin (Na)Fenoprofen may enhance the anticoagulant effect of Warfarin. ModerateDelayedPatients receiving Warfarin should be instructed to not initiate Fenoprofen without consulting his/her healthcare professional (nonacetylated salicylates might be safer alternatives). Acetaminophen is usually a good antipyretic and analgesic choice for patients taking oral anticoagulants.Monitor for increased signs and symptoms of bleeding if Warfarin and Fenoprofen are used concomitantly. Zidovudine These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Liver Function Test (LFT)
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Caps, Tab Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Fenprofen should be used with caution in patients with intrinsic coagulation defects and those on anticoagulant therapy. It should be used with caution in patients with compromised cardiac function, hypertension other condition predisposing to fluid retention. It should be used with extra care in the presence of existing controlled infection. Perform periodic auditory (hearing) function test during chronic therapy. Discontinue drug if skin reaction occur.
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