Felodipine

Felodipine is a calcium channel blocker. It lowers the blood pressure by blocking calcium, relaxes the heart muscle and dilates the heart blood vessels. It has been known since the late 1800s that calcium influx was necessary for the contraction of muscle. The discovery of calcium channel in a cardiac muscle was followed by the finding of several diffent type of calcium channel in diffrent tissues. These discoveries provided the necessary mechanisms for the triggering of cardiac and smooth muscle contraction. The discovery of these channels also made possible the developemnet of clinically useful blocking drugs.

Brands
PLENDIL PLENDIL FELPINE FELPINE
Adult Dose
Dose: 5 mg
Single Dose: 5 (5)
Frequency: 24 hourly
Route: PO
Instructions: Initial
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
. It is of Synthetic origin and belongs to Dihydropyridine. It belongs to Calcium L-channel antagonist pharmacological group on the basis of mechanism of action. The Molecular Weight of Felodipine is 384.20. Its pKa is
Contraindications
Felodipine
Effects
The signs and symptoms that are produced after the acute overdosage of Felodipine include Bradycardia, Hypotension.The symptomatic adverse reactions produced by Felodipine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Fatigue, Palpitation, Rashes, Pruritus, Flushing, Ankle swelling, dizziness.
Indications
Felodipine is primarily indicated in conditions like Angina, Hypertension, Prophylaxis of angina.
Interactions
Felodipine is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAmobarbitalBarbiturates reduces hypotensive effects of Felodipine.MajorCarbamazepineCarbamazepine reduces effects of Felodipine.MajorCimetidine (HCl)DigoxinErythromycinItraconazoleMetipranololInfrequent reports of FELODIPINE increasing the NEGATIVE INOTROPIC effect of METIPRANOLOL [EYE]. ModerateOxcarbazepineAfter repeated coadministration of Oxcarbazepine, the AUC of felodipine was lowered by 28%.Phenytoin (Na)QuinidineRifampicinVORICONAZOLEVoriconazole may increase the serum concentration of felodipine by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of felodipine if voriconazole is initiated, discontinued or dose changed. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Increased in Serum Aminotransferase
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store in a well closed container, Below 40°C. Protect from Sunlight and Moisture.
Warnings
Felodipine should be used with caution in patients with pre-existing heart disease or liver disease.This drug should be used only if clearly needed during pregnancy or lactation. Limit alcohol while taking this medication because it can enhance dizziness. Avoid drinking grapefruit juice at the same time when take this medication.This medication may cause enlargement of the gums, this can be minimized by maintaining good oral hygiene with regular brushing, flossing and massaging of the gums.
Back to List

Any information that appears on this website page is provided for the purpose of general information. This website has been compiled in good faith by HMIS.Online. However, no guarantee is made as to the completeness, validity or accuracy of the information it contains.