Etretinate

Etretinate is aromatic retinoid. Etretinate is effective in the treatment of severe psoriasis and other serious disorders of skin. Etretinate is anticipated that in the near future it will most likely be replaced by its active metabolite etretin because of latters shorter elimination half life.

Brands
Adult Dose
Dose: 0.25 to 0.5 mg/kg
Single Dose: 0.38 (0.375)
Frequency: 24 hourly
Route: PO
Instructions: -
Neonatal
Paedriatic
Characteristics
Etretinate also known as Etretinato (OS=DCIT). . It is of Synthetic origin and belongs to Retinoid. It belongs to Dermatological Products and Retinoic Acid Derivative pharmacological group.The Molecular Weight of Etretinate is 354.50.
Contraindications
Etretinate is contraindicated in conditions like Diabetes mellitus,Pregnancy.
Effects
The severe or irreversible adverse effects of Etretinate, which give rise to further complications include Congenital malformation, Abortions, Hyperlipidemic effects, Osseous abnormalities, Intracranial hypertension.Etretinate produces potentially life-threatening effects which include Hepatotoxicity, Vit A overdosage, Elevation of liver enzymes. which are responsible for the discontinuation of Etretinate therapy.The signs and symptoms that are produced after the acute overdosage of Etretinate include Drowsiness, Irritability, Vit A poisoning, Severe headache, Nausea & vomiting.The symptomatic adverse reactions produced by Etretinate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Itching, Cheilitis, Conjunctivitis, Nasal bleeding, Eczematous rash.
Indications
Etretinate is primarily indicated in conditions like Autosomal dominant ichthyosis, Bullous dermatoses, Dariers disease, Epidermal neoplastic disorders, Keratiniztion disorders, Lichen planus, Nevus unius laterlis, Psoriasis, Sex-linked ichthyosis.
Interactions
Etretinate is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementMethotrexateEtretinate potentiate the risk of hepatitis when it is given with methotrexate.MajorCombination is considered contraindicated.Phenytoin (Na)Retinol (Vitamin A)Tetracycline (HCl) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Elevations of SGPT and SGOT Increased Alkaline Phosphatase LevelsElevation in ALT or ASTIncreased in serum creatininElevation in BUNElevation of LDH
Risks
Drug should not be given to Pregnant Mothers, Cardiac / Hypertensive Patients, patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Cap Store at room temperature. Protect from Sunlight.
Warnings
It should be used with caution in patients with acute, severe and progressive disturbances of consciousness. Administered with hemostatic intracranial pressure relieving drugs or use measures to keep body temperature low.
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