Etoposide

Etoposide is anticancerous drug. Etoposide is a semi-synthetic derivative of podophyllotoxin and extracted from the root of the mayapple. Etoposide is effective in the treatment of different cancers such as carcinoma of lungs, bladder, acute myelocytic leukemia, and lymphoma to slow or stop the growth of abnormal or cancerous cells. Etoposide is used in combination with other anticancerous drugs for the treatment of different tumors and cancers to obtain most excellent therapeutic effects and to reduce toxicity or side effects.

Brands
FYTOSID ETOPUL VEPESID VEPESID ONCOSIDE TOPOSIDE ETOPOSIDE ETOPOSID LASTET ETOSIDE ETOCID
Adult Dose
Dose: 50 to 120 mg/sq.meter
Single Dose: 85 (85)
Frequency: 24 hourly
Route: Slow IV
Instructions: Over 30-60 Minutes for 5 Days
Neonatal
Dose: Doses not established for this age group
Single Dose:
Frequency:
Route:
Instructions:
Paedriatic
Dose: Doses not established for this age group
Single Dose:
Frequency:
Route:
Instructions:
Characteristics
. It is of Synthetic origin and belongs to Glucoside. It belongs to DNA Topoisomerase II Activator pharmacological group on the basis of mechanism of action and also classified in Antineoplastic Agent, Plant Derivative pharmacological group.The Molecular Weight of Etoposide is 588.60.
Contraindications
Etoposide is contraindicated in conditions like Hepatic disease.
Effects
The severe or irreversible adverse effects of Etoposide, which give rise to further complications include Nausea, Vomiting, Alopecia, Hypotension, Anaphylactoid reactions.Etoposide produces potentially life-threatening effects which include Thrombocytopenia, Myelosuppression, Leucopenia. which are responsible for the discontinuation of Etoposide therapy.The symptomatic adverse reactions produced by Etoposide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Anorexia, Diarrhea, Abdominal pain.
Indications
'Etoposide is primarily indicated in conditions like NSAID-associated ulceration, Resistant non-seminomatous testicular cancer, Small cell carcinoma, Small cell lung cancer, and can also be given in adjunctive therapy as an alternative drug of choice in Acute leukemia, AIDS-related kaposi sarcoma, Gastric cancer, Gestational tophoblastic tumors, Gestational trophoblastic tumors, Hodgkin''s disease, Neuroblastoma, Non-hodgkin''s lymphoma, Non-small cell lung carcinoma, Ovarian cancer, Testicular seminoma.'
Interactions
Etoposide is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCisplatinVORICONAZOLEVoriconazole may increase the serum concentration of etoposide by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of etoposide if voriconazole is initiated, discontinued or dose changed These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Caps, Inj Store Below 40°C. Protect from Sunlight.
Warnings
Etoposide must not be used by women who are or may become pregnant or while nursing. Etoposide should be used cautiously in patients who have had previous myelosuppressive therapy such as chemotherapy or radiation therapy. Patients with active infection should be treated prior to receiving etoposide, the dose should be reduced or discontinued in patients who develop such infections. Etoposide should be used with caution in patients with dental disease. Dental work should be performed prior to initiating etoposide therapy, or deferred until blood counts return to normal. It should be used with caution in patients with renal impairment.
Back to List

Any information that appears on this website page is provided for the purpose of general information. This website has been compiled in good faith by HMIS.Online. However, no guarantee is made as to the completeness, validity or accuracy of the information it contains.