Etodolac

Etodolac is a newer pyranoindole acetic acid derivative. Etodolac is NSAID (non-steroidal anti-inflammatory drug). It relieves pain and reduces fever and inflammation. Etodolac is a racemic mixture of R and S forms, the R form being inactive. itused to treat pain, swelling and stiffness associated with arthritis.

Brands
Adult Dose
Dose: 2.857 to 4.285 mg/kg
Single Dose: 3.6 (3.571)
Frequency: 12 hourly
Route: PO
Instructions: -
Neonatal
Paedriatic
Dose: Doses not established for this age group
Single Dose:
Frequency:
Route:
Instructions:
Characteristics
. It is of Synthetic origin and belongs to Pyranoindole Acetic Acid. It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action and also classified in Analgesics and Anti-inflammatory Agents pharmacological group.The Molecular Weight of Etodolac is 287.40. Its pKa is 4.65.
Contraindications
Etodolac is contraindicated in conditions like Peptic ulcer,GI hemorrhage.
Effects
The severe or irreversible adverse effects of Etodolac, which give rise to further complications include Thrombocytopenia, Leucopenia.Etodolac produces potentially life-threatening effects which include Gastrointestinal hemorrhage. which are responsible for the discontinuation of Etodolac therapy.The signs and symptoms that are produced after the acute overdosage of Etodolac include Upper gastrointestinal irritation.The symptomatic adverse reactions produced by Etodolac are more or less tolerable and if they become severe, they can be treated symptomatically, these include Indigestion, Photosensitivity reactions.
Indications
Etodolac is primarily indicated in conditions like Endometrial thinning before intra-uterine surgery, Osteoarthritis, Pain and inflammation in rheumatoid arthritis, Rheumatoid arthritis.
Interactions
Etodolac is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholCyclosporin ANateglinideConcurrent use may potentiate the hypoglycemic action of Nateglinide.Phenylbutazone Phenytoin (Na)Warfarin (Na)Zidovudine These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
False positive test for urinary bilirubin.
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Store Between 20°C-25°C. Tab, Caps Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Etodolac should be used with caution in patients with liver or kidney disease, blood disorders, ulcers, heart disease, alcohol use, high blood pressure, eye disease or allergy, especially drug allergy. It should be used with caution when performing tasks requiring alertness. Limit alcohol intake as it may intensify the drowsiness effect of this medication and make stomach or intestines more likely to bleed. Do not take aspirin without consulting the doctor. Caution is advised when this drug is used in the elderly patients. This medication should be used during pregnancy or lactation only if clearly needed. The use of this drug in the last 6 months of pregnancy is not recommended.
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