Etidronate (Disodium)

'Etidronate is a diphosphonate compound, ethane-1-hydroxy-1,1-diphosphonate. It helps to maintain calcium levels and bone metabolism. Etidronate (Disodium) is used to treat osteoporosis and symptoms of paget''s disease (bone weakening disease). Etidronate (Disodium) is also used after hip replacement or spinal cord injury.'

Brands
ETIDRON ETINAT ETINAT ETINAT
Adult Dose
Dose: 5 to 20 mg/kg
Single Dose: 12 (12.5)
Frequency: 24 hourly
Route: PO
Instructions: For max 6 Months
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose: Safety not established
Single Dose:
Frequency:
Route:
Instructions:
Characteristics
. It is of Synthetic origin and belongs to Diphosphonate. It belongs to Osteoclast inhibitor pharmacological group on the basis of mechanism of action and also classified in Biphosphonate Derivative pharmacological group.The Molecular Weight of Etidronate (Disodium) is 250.00. Its pKa is 3.0, 2.2, 7.2, 11.1.
Contraindications
'Etidronate (Disodium) is contraindicated in conditions like Osteolytic paget''s disease,Pregnancy,Breast feeding,Pain and inflammation (rheumatic disease),Vasomotor symptoms in estrogen deficiency, see instruction.'
Effects
The severe or irreversible adverse effects of Etidronate (Disodium), which give rise to further complications include Hypersensitivity rashes.Etidronate (Disodium) produces potentially life-threatening effects which include Worsening of Pre-existing renal impairment, Acute Renal Failure, Acute renal failure. which are responsible for the discontinuation of Etidronate (Disodium) therapy.The signs and symptoms that are produced after the acute overdosage of Etidronate (Disodium) include Acute renal failure.The symptomatic adverse reactions produced by Etidronate (Disodium) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Osteomalacia, Pathalogical fracture, Transient taste disturbances, Gastrointestinal Intolerance.
Indications
Etidronate (Disodium) is primarily indicated in conditions like Bone (pagets) disease, Hypercalcaemia of malignancy, Postmenopausal osteoporosis.
Interactions
Etidronate (Disodium) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAluminium Hydroxide and OxideCalciumCalcium salts reduce absorption of Bisphosphonates (e.g Etidronate). Iron SaltsTechnetium Tc-99m OxidronateEtidronate may interfere with bone uptake of technetium Tc 99m oxidronate. Dscontinuation of etidronate therapy before performance of a bone scan with technetium Tc 99m oxidronate is recommended for a 2-week period. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Interpretation of radionuclide bone scans.
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Store Between 20°C-25°C. Tab Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Patients who are on calcium and vitamin D restriction may be more sensitive to the effects of etidronate. Patients should be sure to maintain appropriate dietary intake of vitamin D and calcium while receiving this medication. Etidronate can cause diarrhea, particularly when high doses are administered, and the drug should be used with caution, if at all, in patients with enterocoliti. It should be used with caution in patients with renal impairment or a decreased glomerular filtration rate. It should be used during pregnancy only if the potential benefits to the mother outweighs thepotential risks to the fetus.
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