ENAMID USEMID ETHOMID

Dose: 250 to 1000 mg
Single Dose: 620 (625)
Frequency: 12 hourly
Route: PO
Instructions: The drug is best taken with meal in divided doses to avoid GI irritaion

Dose: Doses not established for this age grioup
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Ethionamide also known as Jrecator. . It is of Synthetic origin and belongs to Carbothioamide. It belongs to Antimycobacterial agent pharmacological group on the basis of mechanism of action. The Molecular Weight of Ethionamide is 166.20. Its pKa is HA: 12.14, BH: 4.34.

Ethionamide is contraindicated in conditions like Hepatic damage,Chronic resistant vaginal candidiasis.

The severe or irreversible adverse effects of Ethionamide, which give rise to further complications include Encephalopathy, Convulsions, Hepatotoxicity, Hepatitis, Hypersensitivity reactions, Anxiety, Optic neuritis, Depression, Hepatotoxicity, Acute psychosis, Optic neuritis.The symptomatic adverse reactions produced by Ethionamide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Vomiting, Alopecia, Anorexia, Diarrhea, Abdominal pain, Stomatitis, Jaundice, Skin rash, Impotence, Hypotension, Taste disturbance, Acne, Gynecomastia, Salivation, Menstrual irregularity, Deafness, Purpura, Menorrhagia, Hypoglycemia, Goiter, Alopecia, dizziness, parasthesia.

Ethionamide is primarily indicated in conditions like Prophylaxis of acid aspiration in obstetric patients, Tuberculosis, and can also be given in adjunctive therapy as an alternative drug of choice in Multibacillary leprosy.

Ethionamide is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholCycloserinepellagra like encephalopathy can occur when both drugs are given in combinationGlibornurideIsoniazid750 mg of ethionamide given with 10 mg /kg of Isoniazid will increase the serum concentration of Isoniazid PyridoxineRifampicinHepatitis occurs with jaundice mostly when both drugs are co administeredSulfapyridineConcurrent use with sulfonamides may result in an increased incidence of hepatotoxicity. Patients, especially those on prolonged administration or those with a history of liver disease.Should be carefully monitored. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Urinary Determination of Alkaline Phosophatase, Lactic dehydrogenase& Phosphate

Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Tab Store at room temperature, Below 25°C. Protect from Sunlight and Moisture.

Ethionamide should be used with caution in patients with any allergy (especially drug allergy), liver disease or diabetes. Limit alcohol intake since alcohol can increase the drowsiness effect of this medication and also affect the liver. It should be used with caution when performing activities requiring alertness. This medication should be used only when clearly needed during pregnancy or lactation.