Ether

In 1842 Dr cranford long of athens, GA, first used it as a general anesthetic. Ether is an organic compound having an oxygen atom bounded to two carbon atoms. Ether is inhalation anesthetic agent. Inhaled gases are the mainstay of anesthesia and are primarily used for the maintenance of anesthesia after administration of an intravenous agent. The depth of anesthesia can be rapidly altered by changing the concentration of inhaled anesthetic.

Brands
Adult Dose
Dose: 3 to 5 %
Single Dose: 4 (4)
Frequency: As recommended.
Route: Inhalation
Instructions: As Required
Neonatal
Dose: 3 to 5 %
Single Dose: 4 (4)
Frequency: As recommended.
Route: Inhalation
Instructions: As Required
Paedriatic
Dose: 3 to 5 %
Single Dose: 4 (4)
Frequency: As recommended.
Route: Inhalation
Instructions: As Required
Characteristics
Ether also known as Diethyl ether. . It is of Synthetic origin and belongs to Oxyethane. It belongs to General Anesthetics-Volatile pharmacological group on the basis of mechanism of action and also classified in General Anesthetics pharmacological group.The Molecular Weight of Ether is 74.20. Its pKa is unionized.
Contraindications
Ether is contraindicated in conditions like Raised intracranial pressure,Pyrexia.
Effects
The severe or irreversible adverse effects of Ether, which give rise to further complications include Cardiac arrest, PT Time, BGL, Capillary Idecding.Ether produces potentially life-threatening effects which include Hypersensitivity reactions, Convulsions, ECG abnormalities. which are responsible for the discontinuation of Ether therapy.The signs and symptoms that are produced after the acute overdosage of Ether include Apnea, Cardiotoxicity.The symptomatic adverse reactions produced by Ether are more or less tolerable and if they become severe, they can be treated symptomatically, these include Vomiting, Disturbed renal function, Hepatic degenerative changes.
Indications
Ether is primarily indicated in conditions like Anesthesia, Status asthmaticus, and can also be given in adjunctive therapy as an alternative drug of choice in Analgesic, Muscle relaxation.
Interactions
Ether is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementKetamine (HCl)Pancuronium (Br)PractololPropranolol (HCl)Sotalol (HCl)Suxamethonium (Cl)Vecuronium (Br) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Urinary Test of Ethanol Test for Catecholamines in plasma.
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inhaler (volatile Liq) Store in a well closed container. Protect from Sunlight.
Warnings
It should not be used in period of metabolic stress. Deep ether anesthesia should be avoided in any patients with serious systemic disease, especially of cardiovascular system, respiratory system, kidneys or liver.
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