Ethambutol (HCl)

Ethambutol (HCl) is oral antimycobacterial agent. Ethambutol (HCl) is a synthetic, water soluble, heat stable compound. Ethambutol (HCl) is specifically effective against actively growing micro-organism of genus Mycobacterium including M. tuberculosis. Resistance to ethambutol emerges rapidly when the drug is used alone. Therefore Ethambutol (HCl) is always given in combination with other antituberculosis drug.


Adult Dose
Dose: 15 to 25 mg/ kg
Single Dose: 20 (20)
Frequency: 24 hourly
Route: PO
Instructions: Initially for 60 Days.
Neonatal
Dose: SA
Single Dose:
Frequency:
Route:
Instructions:
Paedriatic
Dose: 15 mg/kg
Single Dose: 15 (15)
Frequency: 24 hourly
Route: Oral
Instructions: Maintenance As Required
Characteristics
Ethambutol (HCl) also known as Ethambutol. . It is of Synthetic origin and belongs to Ethylaminobutan. It belongs to Antimycobacterial agent pharmacological group on the basis of mechanism of action. The Molecular Weight of Ethambutol (HCl) is 277.20. Its pKa is 6.3.
Contraindications
Ethambutol (HCl) is contraindicated in conditions like Optic neuritis.
Effects
The severe or irreversible adverse effects of Ethambutol (HCl), which give rise to further complications include Thrombocytopenia, Retrotubular neuritis, Pulmonary infiltrates.The symptomatic adverse reactions produced by Ethambutol (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Anorexia, Fever, Abdominal pain, Confusion, Hallucination, Malaise, Disorientation, Hyperuricemia, Joint pain, GI disturbance, Allergic rashes, Confusion, dizziness, Reduction invisual acuity, Green-red colour blindness.
Indications
Ethambutol (HCl) is primarily indicated in conditions like Acute leukemia, Non-tuberculous mycobacterial infection, and can also be given in adjunctive therapy as an alternative drug of choice in Tuberculosis.
Interactions
Ethambutol (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAluminium Hydroxide and OxideBromazepam These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
False Positive Screening Test for Phaeochromocytoma
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store Below 40°C. Protect from Sunlight, Moisture and Heat.
Warnings
Ethambutol should be used with caution in patients with history of gout, kidney disease or vision problems, such as cataracts. It should be used with caution during pregnancy or lactation.
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