Acetylcysteine

Acetylcysteine is the N-acetyl derivative of naturally occuring amino acid L-cysteine. It is a mucolytic agent and works on the lung to make the mucous thin, facilitate their removal and making breathing easier in bronchopulmonary disorders. Acetylcysteine is administered by instillation or nabulization. it is available in combination with hypermellose.

Brands
CICATRIN CICATRIN RINOFLUIMUCIL FLUIMUCIL-A FLUIMUCIL-A ACETYL AMINOPLASMAL® HEPA MUCOLATOR AMINORAINS
Adult Dose
Dose: 1%
Single Dose: 1 (1)
Frequency: 8 hourly
Route: Intra Nasal
Instructions: 2 nebulizations in each nostril.
Neonatal
Dose: 0.125 mg/kg/min
Single Dose: 0.12 (0.125)
Frequency: As recommended.
Route: Infusion
Instructions: Maintenance, over 20 hrs., As required
Paedriatic
Dose: 0.125 mg/kg.min
Single Dose: 0.12 (0.125)
Frequency: As recommended.
Route: IV Infusion
Instructions: Maintenance for 20 Hours, As Required
Characteristics
Acetylcysteine also known as L-cysteine. . It is of Synthetic origin and belongs to Mercaptoalanine. It belongs to Mucolytic Agents pharmacological group on the basis of mechanism of action and also classified in Respiratory Inhalant Products and Antidotes pharmacological group.The Molecular Weight of Acetylcysteine is 163.20. It is strongly acidic drug, 4.58% solution of the drug is isotonic and Its pKa is 3.2, 11.2, 9.65.
Contraindications
Acetylcysteine
Effects
Acetylcysteine produces potentially life-threatening effects which include Anaphylactoid reactions. which are responsible for the discontinuation of Acetylcysteine therapy.The signs and symptoms that are produced after the acute overdosage of Acetylcysteine include Flushing, Nausea, Vomiting, Bronchospasm, Edema, Tachycardia.The symptomatic adverse reactions produced by Acetylcysteine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting.
Indications
Acetylcysteine is primarily indicated in conditions like Paracetamol overdosage, Paracetamol poisoning, Viscous sputum, and can also be given in adjunctive therapy as an alternative drug of choice in Atelectasis, Cystic fibrosis, Keratoconjuctivitis sicca, Meconium ileus, Surface anaesthetic.
Interactions
No data regarding the interactions of Acetylcysteine was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inhaler Store Below 40°C. Protect from Sunlight and Heat.
Warnings
Use with caution in patients with asthma or peptic ulcer. Dilute with sterile water for injection as concentration occurs in nebulizer. A face mask may cause stickiness on face after nebulization, remove with water.
Back to List

Any information that appears on this website page is provided for the purpose of general information. This website has been compiled in good faith by HMIS.Online. However, no guarantee is made as to the completeness, validity or accuracy of the information it contains.