Epoetin

Epoetin is a recombinant human erythropoitin, a 165 amino acid glycoprotein produced by Chinese hamster ovary cells into which a human erythropoietin gene has been inserted. Epoetin is used as an antianemic. It increases red blood cells (RBCs) production in body and effective in the treatment of anemia associated with chronic renal failure or dialysis or anemia caused by AZT in HIV-infected persons. Epoetin is administered intravenously or subcutaneously.


Adult Dose
Dose: 75 to 300 IU/ kg
Single Dose: 190 (187.5)
Frequency: As recommended.
Route: IV
Instructions: Maintenance for thrice a Week
Neonatal
Dose: 50 IU/kg
Single Dose: 50 (50)
Frequency: 8 hourly
Route: Intravenous
Instructions: Initially 3 times per week
Paedriatic
Dose: 50 IU/kg
Single Dose: 50 (50)
Frequency: 8 hourly
Route: Intra Venous
Instructions: Initially per week, As required
Characteristics
Epoetin also known as Human Erythropoitin. . It is of Natural origin and belongs to Glycoprotein. It belongs to Erythropoietin agonist pharmacological group on the basis of mechanism of action and also classified in Hematological Agents and Colony Stimulating Factor pharmacological group.The Molecular Weight of Epoetin is 30400.00.
Contraindications
Epoetin is contraindicated in conditions like Erythroid leukaemia,Uncontrolled hypertension.
Effects
Epoetin produces potentially life-threatening effects which include Hyperkalemia, Increased mean arterial BP, Grand mal seizures, Thrombosis. which are responsible for the discontinuation of Epoetin therapy.The symptomatic adverse reactions produced by Epoetin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Shivering, Muscular aches.
Indications
Epoetin is primarily indicated in conditions like Acceleration of myeloid recovery following bone marrow transplantation, Anaemia, and can also be given in adjunctive therapy as an alternative drug of choice in Orthostatic hypotension.
Interactions
No data regarding the interactions of Epoetin was found.
Interfrence
Serum Tests for Uric Acid Complete blood cell count
Risks
Drug should not be given to Geriatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj (reconstituted soln) Store in refrigerator. Do not Freeze. Use within 2 hrs if kept at room temperature.
Warnings
Epoetin should be used with caution in pregnant or nursing women only if clearly needed. It should be used with caution in patients with history of blood clots, heart or blood vessel disease, high blood pressure, porphyria, seizures or problems with bones. This drug may not work if patient have sickle cell anemia. Evaluation of iron stores, by measurement of serum iron, iron-binding capacity, and ferritin, should be undertaken before initiation of treatment.
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