COMBINOL-D PHENSEDYL-P ANGLOMONIA ANGLOMONIA ANGLOMONIA ALCOF D TORANT TORANT TORANT SYREX BILFENESIN BIOCOUGH BIOCOUGH BIOCOUGH PULMONOL PULMONOL PULMONOL DOSACOREX-D DORAX DORAX COFSONIL COFSONIL CAMCOUGH CAMCOUGH CAMCOUGH PULMOBEX FEROCOL-D BRONOCHOL BRONOCHOL EPONIUM EPONIUM COCIL HISTAMOL-D HISTAMOL-D AMCODRIN AMCODRIN AMCODRIN GLOBODRIN COUGHSODEX EPHEDRINE EXPETUS EXCOLD EXCOLD EXCOLD PEXOL PEXOL ASMOL LIZRIN LIZRIN LIZRIN RENESED RENESED METRAFED METRAFED AMCOF AMCOF GLYCODIN GLYCODIN GLYCODIN AMMONIUM CHLORIDE AMMONIUM CHLORIDE AMMONIUM CHLORIDE TRIPOFED TRIPOFED TRIPOFED NOSCABINE NOVOFIED-P NOVOFIED-P NOVOFIED-P EPHEDRINE AMMOTUS UNIREX-D UNIREX-D BRONCODYL-D BRONCODYL-D AMCHLO AMCHLO ORODIL ORODIL ASMASAL ASMASAL DAVEDIX MANURAX AMONAF EPHAZOL-C AMMODRYL AMMODRYL DIPHENE COMPOUND DIPHENE COMPOUND AMCHOL AMCHOL AMCHOL CODOHYST LIGNOCAINE COMP RELTUS EXPECTORANT DAVENOL MARAX COREX-D COREX-D SEPTEM DELTARHINOL AMMONICA AMMONICA AMMONICA DEKUF ZICOL ABENOL PLUS VIGROL FORTE PLIPHID SORAX SPENSID SANSI SEMOCOF SEMOCOF SEMOCOF EPHERIN EPHEDRINE HCL EFED ZECOF ZECOF ZECOF PRODEIN PRODEIN PRODEIN COUGHSOL VEPRESSOR VEPRESSOR VEPRESSOR AMRON AMRON AMRON AKSIDRIN BROVENOL DIMINOL DIMINOL BROVENOL DM BROVENOL DM TUSSEX AMYDRINE AMYDRINE DEECHLORIDE DEECHLORIDE DEECHLORIDE DELMON ENMOL ENMOL ENMOL COUGHNOL FREECOS FREECOS FREECOS MB-COF LISKOZ LISKOZ AMCORIDE AMCORIDE AMCORIDE EFDRIN EFDRIN KOFKODIL EPHEDRA REMISOLE REMISOLE REMISOLE RHINOSONE BABY RHINOCOL RHINOSONE-P PHENCODIN COFRADIN COFRADIN COFRADIN ASTHYLINE COFSED COFSED LIGNO COUGH-FLU COUGH-FLU EPHEDRINE PHOLCODINE COMPOUND AMONIUM CHLORIDE AMONIUM CHLORIDE ASOVIL F-DRINS MUCOF PALADIN-E PALADIN-E TRACODIL DM AMMORIDE AMMORIDE AMMORIDE RONDEC RONDEC LIGNOCAINE COMPOUND EPHEDRINE EXPECTO EXPECTO EXPECTO METONE METONE KOF-S COUGHTIN EXPECTORANT EFEDRA E-DRINE E-DRINE

Dose: 25 to 50 mg
Single Dose: 38 (37.5)
Frequency: As recommended.
Route: IM,SC,Slow IV
Instructions:

Dose: 0.5 to 1 %
Single Dose: 0.75 (0.75)
Frequency: As recommended.
Route: Nasal
Instructions: As required

Dose: 0.5 to 1 %
Single Dose: 0.75 (0.75)
Frequency: As recommended.
Route: Nasal
Instructions: As Required

Ephedrine also known as Ephedrium, Ephedrium, Ephedrium, Ephedrium. Eedrynum hidratum, Eedrynum hidratum are the derivatives of Ephedrine. It is of Natural/Synthetic origin and belongs to Ephedra Alkaloid. It belongs to Alpha & Beta adrenergic agonist pharmacological group on the basis of mechanism of action and also classified in Drugs used in Shock and Alpha-Beta Blocker pharmacological group.The Molecular Weight of Ephedrine is 201.70. It is weakly acidic drug, 3.20% solution of the drug is isotonic and Its pKa is 9.6.

Ephedrine is contraindicated in conditions like Hypertension,Thyrotoxicosis,Ischaemic heart disease,Prostatic hypertrophy.

The severe or irreversible adverse effects of Ephedrine, which give rise to further complications include Psychosis, Cardiopathy.Ephedrine produces potentially life-threatening effects which include Central Stimulation, Acute cardiovascular stimulation. which are responsible for the discontinuation of Ephedrine therapy.The signs and symptoms that are produced after the acute overdosage of Ephedrine include Nausea, Vomiting, Tachycardia, Convulsions, Coma, Fever, Palpitations, Respiratory depression, Hypertension, Paranoid psychosis.The symptomatic adverse reactions produced by Ephedrine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Anxiety, Restlessness, Tachycardia, Tremors, Insomnia, Nasal congestion, Local irritation.

Ephedrine is primarily indicated in conditions like Bronchial asthma, Diabetic neuropathic edema, Hypotension, Narcolepsy, Nasal congestion, Nocturnal enuresis, Reduction of neutropenia-related risk of infection, Reversible airways obstruction, and can also be given in adjunctive therapy as an alternative drug of choice in CNS stimulation, Myasthenia gravis, Stokes-adams attack.

Ephedrine is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAcetazolamide (Na)AdrenalineAlbuterolShould not use concurrently without doctors prescription.AlcoholDexamethasoneEphedrine increase urinary excretion of DexamethasoneDexamethasoneDoxapramBoth drugs acts additively.Ephedrine exacerbate the adrenergic response to doxapram thus increases the blood pressure and heart rate.ModerateClosely monitor pulse and blood pressureDoxepin (HCl)Ergometrine (Maleate)Both agents acts additively and synergistically to produce vasoconstriction results in increased blood pressure.ModerateConcomitant use is considered contraindicated. Closely monitor for response and tolerance of patient. Ergotamine (Tartrate)Ergotamine significantly increases the blood pressure by synergistic vasoconstriction due to alpha adrenergic agonist activity of ephedrine.ModerateClinical monitoring of response, tolerence and excessive vasoconstriction is recommended. Patient advised to notify if numbness,tingling,muscle pain,weakness and chest pain signs appears.FurazolidoneBoth agents act synergistically affecting the sympathomimetic activity in this way that furazolidone enhances the storage of norepinephrine in adrenergic neuron and ephedrine increases its liberation result in severe hypertension and hyperpyrexia.MajorBoth agents should not be used in combination.There should be gap of atleast 14 days before initiation of ephedrine therapy and discontinuation of therapy with furazolidone.Halothaneconcomitant administration should be avoided with anesthetic such as halothane , cyclopropaneHyoscine (Butylbromide)IsocarboxazidLevodopaMaprotiline (HCl)Maprotiline interfere with the pressor effect of ephedrine.MinorMonitor the patient`s blood pressure regularly.MoclobemideNitroglycerinEphedrine oppose the vasodilatory actions of nitroglycerin and may cause angina. Noradrenaline (Acid Tartrate)OxprenololConcomitant use may cause hypertensive reactions.Oxytocinconcomitant administration may lead to vasoconstrictive effectPhenobarbitonePhenylpropanolamine (HCl)There is an increase in blood pressure and heart rate if this combination is used.ModerateThis combination is used cautiously and should monitor pulse and blood pressure.ProcarbazineBoth agents act synergistically affecting the sympathomimetic activity in this way that procarbazine enhances the storage of norepinephrine in adrenergic neuron and ephedrine increases its liberation result in severe hypertension and hyperpyrexia.MajorBoth agents should not be used in combination.if necessary 14 days discontinuation of procarbazine must take before initiastion of ephedrine therapy.Quinagolide (HCl)Quinidinetheir is risk of arrythmias when ephedrine co administered with cardiac glycosides such as quinidine or TCAsRauwolfia ReserpineReserpineSelegiline (HCl)SibutramineSodium AcetateAlkalization of the urine decreases the urinary excretion increases the elimination half-life of ephedrine.ModeratePatients should be monitored for toxic effects such as tremor, anxiety, insomnia, irritability, or nervousness. Dosage reductions may be required.Sodium BicarbonateTheophyllineCoadministration may increases the side effects of theophylline because of synergistic pharmacological effects.MinorClosely monitor the patient for side effects of theophylline.Tranylcypromine (Sulphate)Ephedrine precipitate the hypertensive crises associated with tranylcypromine by acting synergistically to enhanced norepinephrine storage in adrenergic neurons and increases secretion of catecholamines.MajorCoadministration is considered contraindicated. There should be gap of atleast 14 days between initiation of therapy with ephedrine and discontinuing tranylcypromine.Trimipramine (Maleate) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Elixir, Nasal Spray Store in a well closed container, Below 40°C. Do not Freeze. Protect from Sunlight. Tab, Inj, Caps Store in a well closed container, Below 40°C. Protect from Sunlight.

Ephedrine should be used with caution in patients of heart disease, cardiac arrhythmias, angina pectoris, renal impairment, diabetes, hypertension. Avoid intraneural and intravascular injection.