Enoxacin

'Enoxacin is a fluoroquinolone antibiotic. They are relatively non-toxic, well tolerated broad spectrum agents. Their excellent bioavailibilty permits their use for treatment of variety of serious bacterial infections.Enoxacin is antibiotic used to treat infections of the urinary tract and sexually transmitted diseases. It''s act by inhibiting DNA gyrase and topoisomerase IV, which are essential enzymes in the reproduction of bacterial DNA.'

Brands
ENOBACT BACNOX ENOXAZAN ENOXAQUIN EDENCIN ENOXA ENOXABID ENOXABID ENOSAF NOXIBAC
Adult Dose
Dose: 200 to 400 mg
Single Dose: 300 (300)
Frequency: 12 hourly
Route: PO
Instructions:
Neonatal
Paedriatic
Characteristics
Enoxacin also known as Enoxacinum. . It is of Synthetic origin and belongs to Quinolone. It belongs to DNA Gyrase inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotics pharmacological group.The Molecular Weight of Enoxacin is 320.30.
Contraindications
Enoxacin is contraindicated in conditions like Tendinitis,Hypersensitivity to the drug.
Effects
The severe or irreversible adverse effects of Enoxacin, which give rise to further complications include Hallucinations, Hallucinations, Eosinophilia, Eosinophilia, Elevated SGPT & SGOT, Seizures, Depression.The symptomatic adverse reactions produced by Enoxacin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Drowsiness, Diarrhea, Anxiety, Tremors, Insomnia, Abdominal pain, Confusion, Photosensitivity, Dyspepsia, Depression, Arthralgia, Nausea and vomiting, Seizures and convulsions, Confusion, dizziness, dyspepsia.
Indications
Enoxacin is primarily indicated in conditions like Bacterial infections, GI infections, Respiratory tract infections, Skin infections, Soft tissue infections, Urethritis, UTI.
Interactions
Enoxacin is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCaffeineFenbufenProbenecidRoflumilastRoflumilast interacts with dual CYP34A/1A2 INHIBITOR like enoxacin and cimetidine where it result in an 59% increase in the roflumilast PDE4 inhibitory effect.TheophyllineTizanidine These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Elevations of SGPT and SGOT Elevation in ALT or AST
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store in a well closed container, Below 40°C.
Warnings
Enoxacin should be used with caution in patient with epilepsy, kidney disease, tendon problems, nervous system disorders, liver disease and of any allergy, including drug allergy. It should be used with caution while driving or performing tasks requiring alertness because it may produce dizziness or lightheadedness. Limit alcohol intake. Photosensitization may occur, so avoid prolonged sun exposure, wear protective clothing and use a sunscreen when outdoors. This medication should be used only when clearly needed during pregnancy or lactation.
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