Emetine (HCl)

Emetine (HCl) is alkaloid obtained from ipecac or synthesized by methylation of cephaeline. Emetine (HCl) is antiprotozoal agent. Emetine (HCl) is used as an antiamebic. Emetine (HCl) is administered subcutaneously or intramuscularly.


Brands
Adult Dose
Dose: 0.857 mg/kg
Single Dose: 0.86 (0.857)
Frequency: 24 hourly
Route: IM
Instructions: For 10 Days
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
. It is of Natural origin and belongs to Ipecac Alkaloid. It belongs to Amebicides pharmacological group.The Molecular Weight of Emetine (HCl) is 679.70. It is weakly acidic drug and Its pKa is 7.4, 8.3.
Contraindications
Emetine (HCl) is contraindicated in conditions like Polyneuritis,Heart disease.
Effects
The severe or irreversible adverse effects of Emetine (HCl), which give rise to further complications include Muscular weakness, Abscess formation, Abscess Formation, Neurosis.Emetine (HCl) produces potentially life-threatening effects which include Myocarditis. which are responsible for the discontinuation of Emetine (HCl) therapy.The symptomatic adverse reactions produced by Emetine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Dizziness, Headache, Fatigue, Diarrhea, Dyspnea, Tachycardia, Local reactions, GI upset, Nausea and vomiting, ECG changes, Fall in BP, Aching joints, Tenderness, Stiffiness, dizziness, Skin lesion.
Indications
Emetine (HCl) is primarily indicated in conditions like Amoebic dysentry, Amoebic granulomata, Amoebic skin lesion, Hepatic amoebiasis.
Interactions
No data regarding the interactions of Emetine (HCl) was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Cardiac / Hypertensive Patients.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Protect from Sunlight.
Warnings
It can be used in all age groups provided that the precaution are taken. The drug may be used during pregnancy if absolutley essential. The drug should be used in reduced dosage in elderly patients. Patients receiving emetine should be closely supervised. ECG monitoring is advised during treatment with emetine. Avoid emetine in patients with cardiac, renal or neuromuscular diseases.
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