Dose: 0.029 to 0.143 mg/kg
Single Dose: 0.086 (0.086)
Frequency: As recommended.
Route: IV
Instructions: As Required

Dose: 0.1 mg/kg
Single Dose: 0.1 (0.1)
Frequency: As recommended.
Route: Slow intravenous
Instructions: Single dose

Dose: 0.1 mg/kg
Single Dose: 0.1 (0.1)
Frequency: As recommended.
Route: Intra Venous
Instructions: Once in divided doses

Edrophonium (Cl) also known as Edrophonium. . It is of Synthetic origin and belongs to Alkylammonium Salt. It belongs to Cholinestrase inhibitor pharmacological group on the basis of mechanism of action and also classified in Antidotes and Diagnostic Aids pharmacological group.The Molecular Weight of Edrophonium (Cl) is 201.70.

Edrophonium (Cl) is contraindicated in conditions like Intestinal obstruction,Urinary obstruction.

The severe or irreversible adverse effects of Edrophonium (Cl), which give rise to further complications include Cardiac arrhythmias, AV-block, Sinus bradycardia, Increased airway resistance.Edrophonium (Cl) produces potentially life-threatening effects which include Neuromuscular blockage, Cardiac Arrest. which are responsible for the discontinuation of Edrophonium (Cl) therapy.The signs and symptoms that are produced after the acute overdosage of Edrophonium (Cl) include Bradycardia, Hypotension, Bronchospasm, Cardiac arrhythmias, Respiratory failure, GI hypermotility, Visual distrubances, Perspiration.The symptomatic adverse reactions produced by Edrophonium (Cl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Diarrhea, Abdominal cramps, Blurred vision, Allergic reactions, Salivation, Lacrimation, Prostatism, Leg cramps, Perioral fasciculation, Periocular fasciculation, Lingual fasciculation.

Edrophonium (Cl) is primarily indicated in conditions like Androgen deficiency and male infertility, Cardiac arrhythmia, Diagnosis of dual block due to suxamethonium, Diagnosis of myasthenia gravis, Influenza A, Myasthenia gravis diagnosis, Neuromuscular blockade reversal, Succinylcholine-induced dual block diagnosis, Treatment of endometriosis.

Edrophonium (Cl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAmpicillinDigoxinEdrophonium may enhance the AV-blocking effect of Digoxin.MajorRapid No action required. LignocaineMetipranololInfrequent reports of EDROPHONIUM increasing the NEGATIVE CHRONOTROPIC effect of METIPRANOLOL [EYE]. ModerateMivacurium (Cl)Pantothenic AcidPantothenic Acid may increase the effects of Edrophonium (Cl).Procainamide (HCl)QuinidineQuinineSuxamethonium (Cl) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

None well documented

Drug should not be given to Pregnant Mothers, Cardiac / Hypertensive Patients, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Inj Store at room temperature. Protect from Sunlight.

Edrophonium should be used with caution in patients with asthma, seizure disorder, epilepsy, heart disease such as hypertension, bradycardia, recent myocardial infraction, in thyroid disorders, intestinal disorders, peptic ulcers, urinary problems or if have any allergy especially to bromides. Large dose by mouth should be avoided in condition where there may be increase absorption from the gastrointestinal tract. It is classified as pregnancy category C and should be used only if clearly needed during pregnancy.