Droperidol

Droperidol is a drug of the butyrophenone series. Droperidol is used for its antianxiety, sedative, tranquilizer and antiemetic effects. Droperidol is a component of neuroleptic anesthesia. Droperidol is used in surgical and diagnostic procedures for its calming effect. It decreases anxiety and pain, reduces nausea and vomiting induced by cancer chemotherapy and may be effective during labor and delivery. Droperidol is administered intramuscularly or intravenously.

Brands
Adult Dose
Dose: 0.071 to 0.214 mg/kg
Single Dose: 0.14 (0.1425)
Frequency: As recommended.
Route: IV
Instructions: As Required
Neonatal
Dose: 0.3 mg/kg
Single Dose: 0.3 (0.3)
Frequency: As recommended.
Route: Intra Muscular
Instructions: Single Dose
Paedriatic
Dose: 0.3 mg/kg
Single Dose: 0.3 (0.3)
Frequency: As recommended.
Route: Intra Muscular
Instructions: Single Dose
Characteristics
Dehydrobenzoeridol is the derivative of Droperidol. It is of Synthetic origin and belongs to Butyrophenone. It belongs to D2 antagonist pharmacological group on the basis of mechanism of action and also classified in Psychotherapeutic Drugs pharmacological group.The Molecular Weight of Droperidol is 379.40. Its pKa is 7.6.
Contraindications
'Droperidol is contraindicated in conditions like Parkinson''s disease,Comatose states.'
Effects
The severe or irreversible adverse effects of Droperidol, which give rise to further complications include Tardive dyskinesia, Oculogyric crises, Laryngeal dystonias, Cardiac arrest, Acute dystonia.Droperidol produces potentially life-threatening effects which include Arrhythmias, Neuroleptic Malignant Syndrome, Neuroleptic malignant syndrome. which are responsible for the discontinuation of Droperidol therapy.The signs and symptoms that are produced after the acute overdosage of Droperidol include Hypotension, Cardiac arrhythmias, Convulsions, Coma, Respiratory depression, Sedation, Extrapyramidal effects.The symptomatic adverse reactions produced by Droperidol are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Sedation, Akathisia, Hypotension, Gynecomastia, Galactorrhea, Extrapyramidal effects, Dystonic reactions, HyperprolactinemiaX, Oligomenorrhea, Paradoxical effects, Blood dyscrasias, Alertness impairment, dizziness.
Indications
Droperidol is primarily indicated in conditions like Aggression, Anxiety, General anaesthesia, Hyperactivity, Hyperemesis gravidarum, Nausea and vomiting, Regional anaesthesia, Schizophrenia, and can also be given in adjunctive therapy as an alternative drug of choice in Induction, Induction and maintenance of anaesthesia, Sedation, Surgical anaesthesia.
Interactions
Droperidol is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAdrenalineAlcoholFentanyl (Citrate)GuanethidineHaloperidolLevodopaLithiumMetoclopramide (HCl)PhenelzinePimozideTetrabenazineThioridazine (HCl)VORICONAZOLEAdditive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongationZiprasidoneContinue on seperteps These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store in a well closed container, Below 40°C. Protect from Sunlight and Heat.
Warnings
It should be used with caution in elderly and debilitated patients because they are at an increased risk of developing adverse reactions, in patients with cardiac disease, in patients with seizure disorder or who are taking anticonvulsants, in patients with a history of phenothiazine hypersensitivity because of its structural similarities to this class of drugs. It is classified as pregnancy category C drug. It should be used with caution during pregnancy only if the potential benefit outweighs the risk to the fetus. Use with caution in women who are breast feeding. Safety in children under 2 years of age has not been established. It should not be used during procedures designed to accurately ascertain the pulmonary artery pressure because droperidol can decrease pulmonary artery pressure.
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