Doxazosin (Mesylate)

Doxazosin (Mesylate) is a quinazoline derivative that blocks certain of the alpha adrenergic receptors, used as an anihypertensive agent. Doxazosin (Mesylate) is adrenergic alpha1 blocking agent. Doxazosin (Mesylate) is used to treat hypertension (high blood pressure). It lowers the blood pressure by relaxing and dilating the blood vessels. It may also be used for treating heart failure and in males for prostate enlargement symptoms such as urinary hesitancy and/or urgency.

Brands
PROSDURA MEZOSIN PROALPHA CARDURA CARDURA URIPAS URIPAS DOZAX DOZAX CARDUCIN CAYDOR CAYDOR OXIZ OXIZ OXIZ
Adult Dose
Dose: 1 mg
Single Dose: 1 (1)
Frequency: 24 hourly
Route: PO
Instructions: Initial Dose
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
. It is of Synthetic origin and belongs to Quinazoline. It belongs to Alpha-1 adrenergic antagonist pharmacological group on the basis of mechanism of action and also classified in Antihypertensive Agents pharmacological group.The Molecular Weight of Doxazosin (Mesylate) is 547.30. Its pKa is 6.93.
Contraindications
Doxazosin (Mesylate)
Effects
The severe or irreversible adverse effects of Doxazosin (Mesylate), which give rise to further complications include Orthostatic hypotension.The symptomatic adverse reactions produced by Doxazosin (Mesylate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Vomiting, Diarrhea, Anxiety, Dyspnea, Palpitation, Insomnia, Lethargy, VertigoX, Somnolence, Edema, Sexual dysfunction, Syncope, Rhinitis, Chest pain, dizziness.
Indications
Doxazosin (Mesylate) is primarily indicated in conditions like Benign prostatic hyperplasia, Hypertension.
Interactions
No data regarding the interactions of Doxazosin (Mesylate) was found.
Interfrence
None well documented
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Store Below 30°C. Tab Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Doxazosin should be used with caution in patients with hepatic disease (the drug is primarily metabolized by the liver) and administration of noral doses of drug may results in exaggerated effects in these patients. Patients with renal impairment should be monitored carefully for exaggerated effects, such as first-dose hypotensive reaction or prolonged hypotension. It is classified as FDA pregnancy category B. This medication should be used only when clearly needed during pregnancy or lactation. Blood pressure should be monitored for 2-6 hours following the first dose and with each subsequent increase in dose because postural hypotensive effects are most likely to occur during this time. Dosages should be adjusted as necessary depending on patient tolerance as evidenced by standing blood pressure. It should not be administered to any patient who has hypotension. Elderly patients are more likely to be susceptible to hypotensive effects.
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