Dose: 0.021 to 0.057 mg/kg.min
Single Dose: 0.039 (0.039)
Frequency: As recommended.
Route: IV
Instructions: As Required

Doxapram (HCl) is the derivative of Doxapram. It is of Synthetic origin and belongs to Phenyl pyrolidine. It belongs to Respiratory Stimulants pharmacological group on the basis of mechanism of action and also classified in CNS Stimulant pharmacological group.The Molecular Weight of Doxapram is 433.00. It is strongly acidic drug.

Doxapram is contraindicated in conditions like Cerebral oedema,Epilepsy,Hypertension,Hyperthyroidism,Phaeochromocytoma,Convulsions,Obstructive airway disease,Heart disease,Cerebrovascular accident,Coronary artery disease,Hypersensitivity,Neonates.

The severe or irreversible adverse effects of Doxapram, which give rise to further complications include Fever, Allergic reactions, Hepatic necrosis, Seizures, Hypertension, Chest pain, Irregular heart beat.Doxapram produces potentially life-threatening effects which include Respiratory Failure, Respiratory failure, Hypoxemia, Hypoxemia. which are responsible for the discontinuation of Doxapram therapy.The signs and symptoms that are produced after the acute overdosage of Doxapram include Tachycardia, Confusion, Sweating, Agitation, Hypertension, Fasciculation of skeletal muscles, Cough, Dyspnea.The symptomatic adverse reactions produced by Doxapram are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Vomiting, Diarrhea, Dyspnea, Sweating, Confusion, Itching, Coughing, Cough, Nausea and vomiting, Skin sensitization, Bronchospasm, Laryngospasm, Micturition problems, Hiccups, Confusion, dizziness.

Doxapram is primarily indicated in conditions like Lung damage, Lung infection, Respiratory depression, Respiratory failure, and can also be given in adjunctive therapy as an alternative drug of choice in Neonatal apnea.

Doxapram is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementEnfluraneEphedrineBoth drugs acts additively.Ephedrine exacerbate the adrenergic response to doxapram thus increases the blood pressure and heart rate.ModerateClosely monitor pulse and blood pressureFurazolidoneBoth agents acts synergistically in inducing sympathomimetic effect. Furazolidone increases the storage of norepinephrine in adrenergic neurons and doxapram enhance liberation or reduce reuptake of catecholamines thus precipitate severe hypertension.MajorCoadministration is considered contraindicated. There should be gap of atleast 14 days between discontinuing of therapy with furazolidone and initiation of treatment with doxapram.HalothaneIsofluraneProcarbazineBoth agents acts synergistically in inducing sympathomimetic effect. Procarbazine increases the storage of norepinephrine in adrenergic neurons and doxapram enhance liberation or reduce reuptake of catecholamines thus precipitate severe hypertensionMajorCoadministration is considered contraindicated. There should be gap of atleast 14 days between discontinuing of therapy with procarbazine and initiation of treatment with doxapram.Selegiline (HCl)Both agents acts synergistically in inducing sympathomimetic effect. Selegiline increases the storage of norepinephrine in adrenergic neurons and doxapram enhance liberation or reduce reuptake of catecholamines thus precipitate severe hypertension.MajorCoadministration is considered contraindicated. There should be gap of atleast 14 days between discontinuing of therapy with selegiline and initiation of treatment with doxapram.Theophylline These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Heart function test

Drug should not be given to Paediatrics, Pregnant Mothers, Cardiac / Hypertensive Patients, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Inj Store Below 40°C. Do not Freeze.

Monitor blood pressure continuously. If sudden hypotension or dyspnea develop, discontinue use of doxapram. It should be used with caution in patients with chronic obstructive pulmonary disease. Hepatic and renal impairment.