PROTHIADEN PROTHIADEN

Dose: 75 to 150 mg
Single Dose: 110 (112.5)
Frequency: 24 hourly
Route: PO
Instructions: Initially at night, increased gradually

Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group

Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group

Dothiepin (HCl) also known as Dosulepin (HCl). . It is of Synthetic origin and belongs to Amitryptyline. It belongs to Amine uptake inhibitor pharmacological group on the basis of mechanism of action and also classified in Psychotherapeutic Drugs and Tricyclin (Tertiary Amine) pharmacological group.The Molecular Weight of Dothiepin (HCl) is 331.90. Its pKa is 8.5.

Dothiepin (HCl) is contraindicated in conditions like Cardiac arrhythmia,Mania,Myocardial infarction,Heart block,Liver diseases,Narrow-angle glaucoma,Prostate disease.

The severe or irreversible adverse effects of Dothiepin (HCl), which give rise to further complications include Convulsions, Cholestatic jaundice, Cholestatic jaundice, Hypomania, Mania, Paranoid delusions.Dothiepin (HCl) produces potentially life-threatening effects which include Bone marrow suppression, Agranulocytosis. which are responsible for the discontinuation of Dothiepin (HCl) therapy.The signs and symptoms that are produced after the acute overdosage of Dothiepin (HCl) include Convulsions, Cardiac dysrhythmias, Blurred vision, Drowsiness, Dry mouth, Unconsciousness, Respiratory depression, Hallucinations, Tremor, Excitation.The symptomatic adverse reactions produced by Dothiepin (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Drowsiness, Irritability, Nausea, Vomiting, Diarrhea, Tachycardia, Constipation, Tinnitus, Sweating, Dry mouth, Blurred vision, Confusion, Urticaria, Skin RashX, Photosensitivity, Sleep disturbance, Tremor, Postural hypotension, Taste disturbance, ECG changes, Hyponatremia, Urinary retention, Accomodation disturbances, Dry mouth, Confusion, dizziness.

Dothiepin (HCl) is primarily indicated in conditions like Anxiety, Cytotoxic chemotherapy, Depression, Depressive illness, Nausea, vomiting (acute attacks), Sedation.

No data regarding the interactions of Dothiepin (HCl) was found.

Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Tab, Caps Store at room temperature, Below 30°C. Protect from Sunlight and Moisture.

Dothiepin has anticholinergic properties, therefore it may precipitate urinary retention in susceptible individuals and its use should be avoided in patients with existing of potential urinary retention. Dotheipin should not be used in patients with closed-angle glaucoma. Caution is advised when treating epileptic patient and those with the cardiovascular disorders. Cautions:- Cardiovascular disease b/c of the arrhythmias, patients with concomitant conditions such as hyperthyroidism and pheochromocytoma should be treated with case. Case is also needed in patients with epilepsy and diabetes. TCA drugs have anti muscarinic activity, and there fore caution is needed in patient with prostatic hypertrophy, increased IOP, urinary retention or those with a susceptibility to angle-closure glaucoma, TCA and related anti-depressants should be used with caution in patients with a significant risk of suicide, or a history of psychosis or bipolar disorders.