Dopamine (HCl)

Dopamine occurs in the CNS naturally in the basal ganglia where it functions as a neurotransmitter as well as in the adrenal medulla. Chemically Dopamine (HCl) is 3, 4-dihydroxyphenethyamine. Dopamine (HCl) is the immediate metabolic precursor to norepinephrine. It can activate a and β adrenergic receptors. It raises the blood pressure and effective in treating acute heart attack. It provides additional pumping strength by stimulating the heart muscle. In some patients, Dopamine (HCl) is used for improving kidney blood supply.

Brands
DOPILAX DOPILAX DOPILAX DOPAMINE TROPIN DOPAMINE DOPATROPIN MYUNGMOON INOPAN MYUNGMOON INOPAN MYUNGMOON INOPAN MYUNGMOON INOPAN DOPAMINE DOPAMINE INOPAN INOPAN INOPAN CARAPAMIN
Adult Dose
Dose: 2 to 5 ug/ kg.min
Single Dose: 3.5 (3.5)
Frequency: As recommended.
Route: IV-Inf
Instructions: Initial, increase gradually.
Neonatal
Dose: 2 to 15 ug/kg.min
Single Dose: 8.5 (8.5)
Frequency: As recommended.
Route: IV Infusion
Instructions: As Required
Paedriatic
Dose: 2 to 15 ug/kg.min
Single Dose: 8.5 (8.5)
Frequency: As recommended.
Route: IV Infusion
Instructions: As Required
Characteristics
. It is of Natural origin and belongs to Catecholamin. It belongs to Dopamine agonist pharmacological group on the basis of mechanism of action and also classified in Drugs used in Shock and Adrenergic Agonist Agent pharmacological group.The Molecular Weight of Dopamine (HCl) is 189.60. Its pKa is 8.8.
Contraindications
Dopamine (HCl) is contraindicated in conditions like Phaeochromocytoma,Thyrotoxicosis,Tachyarrythmia,Ventricular fibrillation.
Effects
The severe or irreversible adverse effects of Dopamine (HCl), which give rise to further complications include Hypertension, Tissue necrosis, Tissue sloughing, Peripheral ischemia.Dopamine (HCl) produces potentially life-threatening effects which include Arrhythmias, Anginal pain, Ventricular arrhythmias. which are responsible for the discontinuation of Dopamine (HCl) therapy.The signs and symptoms that are produced after the acute overdosage of Dopamine (HCl) include Elevation of BP.The symptomatic adverse reactions produced by Dopamine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Vomiting, Dyspnea, Palpitation, Tachycardia, Bradycardia, Elevated blood pressure, Glucose intolerance, Mydriasis, Piloerection, Azotemia.
Indications
'Dopamine (HCl) is primarily indicated in conditions like Acid-related dyspepsia, Cardiogenic shock, Cardiopulmonary resuscitation, Heart failure, Metastatic colorectal cancer, Oliguria, Septic shock, and can also be given in adjunctive therapy as an alternative drug of choice in Parkinson''s disease, Prolactinoma.'
Interactions
Dopamine (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementDobutamine (HCl)Dopexamine (HCl)FluphenazineFurazolidoneBoth agents act synergistically effecting the sympathomimetic activity in this way that furazolidone enhances the storage of norepinephrine in adrenergic neuron and dopamine increases its liberation result in severe hypertension and hyperpyrexia.Majorboth agents should not be used in combination.if necessary 14 days discontinuation of furazolidone must take before initiastion of dopamine therapy.Gonadorelin (HCl)GuanethidineGuanadrel decreases the hypotensive effect of dopamine by depleting the catecholamine stores from adrenergic nerve ending and letter potentiate the pharmacological effect of epinephrine and inhibit the primarily indirect acting amine.ModerateHypertensive agents used the combination with caution.HalothaneIproniazid PhosphateLikely interaction of DOPAMINE HYDROCHLORIDE increasing the HYPERTENSIVE effect of IPRONIAZID. MajorLinezolidMaprotiline (HCl)Maprotiline blunt the pressor effect of dopamine.MinorNo especial precautions are necessary.Noradrenaline (Acid Tartrate)Phenytoin (Na)Coadministration results in severe hypotension by catecholamine depletion and hydantoin-induced myocardial depression.MajorThis combination should be avoided.ProtirelinSodium NitroprussideTolazoline (HCl)Tolazoline (HCl)Tranylcypromine (Sulphate) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Urinary Tests for Amino Acids or Catecholamines Tests for detecting uric acid or urobilinogen
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj (reconstituted soln) Store at room temperature. Do not Freeze. Protect from Sunlight. Use within 24 hrs if kept at room temperature.
Warnings
Dopamine must be used cautiously in patients with heart disease, particularly coronary artery disease, because its actions increase the myocardial oxygen demand. It should be used with caution in individuals with sulfite hypersensitivity (some preparations of dopamine contain sulfites.), since these antioxidant compounds can cause allergic reactions, including anaphylaxis. This reaction appears to be more common in asthmatic than non-asthmatic patients. Dopamine is classified as a pregnancy category C drug. Use during pregnancy should be avoided unless the potentialbenefits outweigh the unknown potential risks to the fetus. Closely monitor urine flow, cardiac output and blood pressure during infusion of dopamine. Infuse into the large vein to avoid necrosis and sloughing of surrounding tissues.
Back to List

Any information that appears on this website page is provided for the purpose of general information. This website has been compiled in good faith by HMIS.Online. However, no guarantee is made as to the completeness, validity or accuracy of the information it contains.