Dose: 0.007 mg/kg
Single Dose: 0.007 (0.007)
Frequency: 24 hourly
Route: IM
Instructions:

Dose: 10 mg
Single Dose: 10 (10)
Frequency: As recommended.
Route: daily
Instructions:

Distigmine (Br) also known as Bispyridostigmine Br. . It is of Synthetic origin and belongs to Carbamoyldipyridine Queutenergy Ammonium compound. It belongs to Cholinestrase inhibitor pharmacological group on the basis of mechanism of action. The Molecular Weight of Distigmine (Br) is 576.30. Its pKa is 12.0.

Distigmine (Br) is contraindicated in conditions like Circulatory insufficiency,GI obstruction,Urinary outflow obstruction.

The severe or irreversible adverse effects of Distigmine (Br), which give rise to further complications include Bronchospasm, AV-block, Sinus bradycardia, Dyspnea, Cholinergic crises.Distigmine (Br) produces potentially life-threatening effects which include Coma, Bradycardia, Convulsions, Neuromuscular blockage, Hypotension, Hypoxemia, Paralysis, Bronchoconstriction, Severe muscle weakness. which are responsible for the discontinuation of Distigmine (Br) therapy.The signs and symptoms that are produced after the acute overdosage of Distigmine (Br) include Nausea, Sweating, Increased peristalsis, Pallor, Retching, Spasticity, Paralysis.The symptomatic adverse reactions produced by Distigmine (Br) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Diarrhea, Abdominal cramps, SweatingX, Miosis, Salivation, Urinary urgency.

Distigmine (Br) is primarily indicated in conditions like Intestinal atony, Neurogenic bladder, Postoperative ileus, Postoperative urinary retention, Prophylaxis of NSAID-associated gastric or duodenal ulcer, and can also be given in adjunctive therapy as an alternative drug of choice in Extravasation/haematoma, Myasthenia gravis.

No data regarding the interactions of Distigmine (Br) was found.

Drug should not be given to Paediatrics, Pregnant Mothers, Cardiac / Hypertensive Patients, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Tab Store Below 25°C. Protect from Moisture.

Distigmine should be used with caution in patients with asthma, seizure disorder, epilepsy, heart disease such as hypertension, bradycardia, recent myocardial infraction, thyroid disorders, intestinal disorders, ulcers, urinary problems or if have any allergy especially to bromides. Large dose by mouth should be avoided in condition where there may be increase absorption from the gastrointestinal tract. It should be used only if clearly needed during pregnancy.