Diphenoxylate (HCl)

Diphenoxylate (HCl) is a synthetic derivative of pethidine with little or no analgesic activity. It reduces the gut motility and is used to treat diarrhea.


Adult Dose
Dose: 5 mg
Single Dose: 5 (5)
Frequency: 8 hourly
Route: PO
Instructions: Initial
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
Diphenoxylate is the derivative of Diphenoxylate (HCl). It is of Synthetic origin and belongs to Meperidine. It belongs to OPIATE agonist (peripheral) pharmacological group on the basis of mechanism of action and also classified in Antidiarrhoeals pharmacological group.The Molecular Weight of Diphenoxylate (HCl) is 489.10. Its pKa is 7.1.
Contraindications
'Diphenoxylate (HCl) is contraindicated in conditions like Ulcerative colitis,Pseudomembranous colitis,Intestinal obstruction,Colitis,Crohn''s disease,Hepatic dysfunction.'
Effects
The severe or irreversible adverse effects of Diphenoxylate (HCl), which give rise to further complications include Pancreatitis, Paralytic ileus, Hyperglycemia, Hemorrhagic colitis, Hyperglycemia, Hemorrhagic colitis, Toxic megacolon.Diphenoxylate (HCl) produces potentially life-threatening effects which include Anaphylactoid reactions, Pseudomembranous colitis, Portosystemic encephalopathy, Inflammatory bowel disease, Portosystemic encephalopathy. which are responsible for the discontinuation of Diphenoxylate (HCl) therapy.The signs and symptoms that are produced after the acute overdosage of Diphenoxylate (HCl) include Flushing, Tachycardia, Coma, Hyperthermia, Urinary retention, Respiratory depression, Nystagmus, Lethargy, Pinpoint pupils, Dry mucous membrane, Hypotonic reflexes, Narcosis.The symptomatic adverse reactions produced by Diphenoxylate (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Abdominal distension, Dizziness, Headache, Drowsiness, Nausea, Vomiting, Anorexia, Restlessness, Confusion, Urticaria, Pruritus, Lethargy, Sedation, Hallucination, Malaise, Depression, SomnolenceX, Euphoria, Hypersensitivity reactions, Paralytic ileus, Gum swelling, Angioedema, Confusion, dizziness, Toxic megacolon.
Indications
Diphenoxylate (HCl) is primarily indicated in conditions like Diarrhoea.
Interactions
No data regarding the interactions of Diphenoxylate (HCl) was found.
Interfrence
False +ve result in screening tests for the presence of barbiturates in serum
Risks
Drug should not be given to Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Liq Store Below 40°C. Do not Freeze. Protect from Sunlight and Moisture. Tab Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Patient should observe caution while driving or performing other task requiring alertness because it may cause drowsiness. Diphenoxylate should be used with caution in patients with impaired liver function. Avoid use in patients with jaundice. It should be used with caution in young children, because of greater variability of response in this age group. It is not recommended for use in infant. Patients with inflammatory bowel disease should be carefully observed if receiving diphenoxylate for sign of toxic megacolon.
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