Dimercaprol

Dimercaprol is a metal complexing agent, used as antidote to poisoninig by arsenic, mercury, lead and sometimes other metals, administered orally.


Brands
Adult Dose
Dose: 1.905 to 3.81 mg/kg
Single Dose: 2.9 (2.8575)
Frequency: 8 hourly
Route: IM
Instructions: Load for Once
Neonatal
Dose: 2.5 to 3 mg/kg
Single Dose: 2.8 (2.75)
Frequency: 4 hourly
Route: Intra Muscular
Instructions: Initially for 2 Days
Paedriatic
Dose: 2.5 to 3 mg/kg
Single Dose: 2.8 (2.75)
Frequency: 8 hourly
Route: Intra Muscular
Instructions: Initially for 2 Days
Characteristics
Dimercaprol also known as BAL. . It is of Synthetic origin and belongs to Dimercaptopropanol. It belongs to Antidotes pharmacological group.The Molecular Weight of Dimercaprol is 124.20.
Contraindications
Dimercaprol is contraindicated in conditions like Hypertension,Hepatic failure,Iron poisoning,Selenium poisoning,Tellurium poisoning,Cadmium poisoning,Organic mercury poisoning.
Effects
The severe or irreversible adverse effects of Dimercaprol, which give rise to further complications include Anemia, Anemia, Anemia, Anemia.Dimercaprol produces potentially life-threatening effects which include Exacerbation of hypertension, Exacerbation of hypertension, Iron toxicity potentiation. which are responsible for the discontinuation of Dimercaprol therapy.The symptomatic adverse reactions produced by Dimercaprol are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Vomiting, Fever, Tachycardia, Abdominal pain, Sweating, Local pain, Increased BP, Tingling of the hand, Lacrimation, Pain at injection site, Lip burning sensation, Mouth burning sensation, Pain at injection site.
Indications
'Dimercaprol is primarily indicated in conditions like Acute dichloroarsine poisoning, Antimony poisoning, Arsenic poisoning, Lead poisoning, Superficial lesions from heavy metals, Wilson''s disease.'
Interactions
No data regarding the interactions of Dimercaprol was found.
Interfrence
Elevations of SGPT and SGOT Thyroid Funtion Test
Risks
Drug should not be given to patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store Below 40°C.
Warnings
Dimercaprol should be used with caution in patients with hypertension or impaired renal function. It should be discontinued or use with extreme caution if acute renal insufficiency develops during treatment. Alkalinization of the urine may protect the kidney during therapy. Dimercaprol should not be given to patients with impaired hepatic function unless due to arsenic poisoning. It should not be used in the treatment of poisoning due to cadmium, iron or selenium because the dimercaprol-metal complexes formed are more toxic than the metal themselves.
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