Diloxanide (Furoate)

Diloxanide (Furoate) is a dichloroacetamide derivative. It acts as amebicidal agent. Diloxanide (Furoate) is used in the treatment of intestinal amebiasis (dysentery) in combination with other drugs. Diloxanide fucoate is a pcodeng and is hydcolyned in the gut to diloxamide (active ingredient)


Adult Dose
Dose: 500 mg
Single Dose: 500 (500)
Frequency: 8 hourly
Route: PO
Instructions: For 10 Days
Neonatal
Paedriatic
Dose: 5 to 10 mg/kg
Single Dose: 7.5 (7.5)
Frequency: 8 hourly
Route: Oral
Instructions: Recommended for 5-12 Yrs of Children
Characteristics
. It is of Synthetic origin and belongs to Anilide. It belongs to Anthelmintics pharmacological group.The Molecular Weight of Diloxanide (Furoate) is 328.20.
Contraindications
Diloxanide (Furoate)
Effects
The symptomatic adverse reactions produced by Diloxanide (Furoate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Flatulence, Nausea, Vomiting, Anorexia, Diarrhea, Abdominal cramps, Urticaria, Esophagitis, Paresthesias, Albuminuria.
Indications
Diloxanide (Furoate) is primarily indicated in conditions like Asymptomatic cyst passers, Eradication, Intestinal amoebiasis, Mild amebic dysentery, Non-dysenteric intestinal amebiasis, Oliguria due to renal failure, Oliguria due to renal failure, Parkinsonism.
Interactions
No data regarding the interactions of Diloxanide (Furoate) was found.
Interfrence
Fecal examination
Risks
Drug should not be given to Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store in a well closed container, Below 40°C. Protect from Sunlight.
Warnings
Diloxanide should be used with caution in patient with symptomatic intestinal amebiasis or extra-intestinal amebiasis, during pregnancy and in childrens less than 2 years of age.
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