Dose: 0.014 mg/kg
Single Dose: 0.014 (0.014)
Frequency: As recommended.
Route: IM
Instructions: Maint, As Req, after 30-60 Min of the Initial Dose

Dihydroergotamine (Mesylate) also known as Dihydroergotamine mesylate dihydergot, Dihydroergotamine mesylate dihydergot, Dihydroergotamine mesylate dihydergot, Dihydroergotamine mesylate dihydergot. . It is of Semi Synthetic origin and belongs to Ergot Alkaloid. It belongs to Alpha adrenergic agonist pharmacological group on the basis of mechanism of action and also classified in Analgesics and Anti-inflammatory Agents and Vasoconstrictor pharmacological group.The Molecular Weight of Dihydroergotamine (Mesylate) is 679.80. Its pKa is 6.35.

Dihydroergotamine (Mesylate) is contraindicated in conditions like Hypertension,Shock,Septicaemia,Coronary insufficiency.

The severe or irreversible adverse effects of Dihydroergotamine (Mesylate), which give rise to further complications include Renal insufficiency.Dihydroergotamine (Mesylate) produces potentially life-threatening effects which include Coronary spasm, Anginal pain. which are responsible for the discontinuation of Dihydroergotamine (Mesylate) therapy.The signs and symptoms that are produced after the acute overdosage of Dihydroergotamine (Mesylate) include Vomiting, ECG alterations, Headache, Peripheral vasoconstriction, Acrocyanosis, Rise in B.P..The symptomatic adverse reactions produced by Dihydroergotamine (Mesylate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Tachycardia, Bradycardia, Nausea and vomiting, Numbness, Tingling of the fingers and toes, Precordial pain.

Dihydroergotamine (Mesylate) is primarily indicated in conditions like Cluster headache, Migraine, Migraine prophylaxis, Vascular headaches, and can also be given in adjunctive therapy as an alternative drug of choice in Orthostatic hypotension.

Dihydroergotamine (Mesylate) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementClarithromycinClarithromycin increases the plasma concentration of dihydroergotamine by inhibiting hepatic metabolism.MajorCoadministration is considered contraindicated. Azithromycin is considered safer alternative of clarithromycin.ErythromycinPlasma concentration of dihydroergotamine is increased by erythromycin due to CYP450 3A4 inhibition responsible for clearance of ergotamines and may result in ergotism.MajorThis combination is contraindicated or azithromycin can be used in place of erythromycin as a better alternative.Heparin (Na) and Heparin (Cl)Isosorbide (Dinitrate)MetaraminolDihydroergotamine and metaraminolhve an additive vasoconstriction effect due to alpha adrenergic agonist activity results in great increase in blood pressure.ModerateDihydroergotamine injection or nasal spray is not advised to use or if required then caution must be taken for patient tolerance.NaratriptanConcurrent use have been reported to cause prolonged vasospastic reactions. Concurrent use is not recommended.NelfinavirNevirapineNitroglycerinoral nitroglycerin enhance bioavailability of dihydroegotamineRitonavirSumatriptanDue to additive pharmacologic effect coadministration of these drugs may results in coronary artery vasospasm,peripheral vascular ischemia and colonic ischemia. MajorThis combination is contraindicated if use within 24 hours. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Drug should not be given to Paediatrics, Pregnant Mothers, Cardiac / Hypertensive Patients, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Aerosol Store at room temperature, Below 25°C. Refrigeration and Freezing is not recommended. Protect from Sunlight and Moisture.

Avoid prolong administration or excessive dosage of dihydroergotamine because of danger of gangrene, ergotism and patients become dependent upon it.