DOLOBIS DOLOBIS

Dose: 3.571 to 7.143 mg/kg
Single Dose: 5.4 (5.357)
Frequency: 12 hourly
Route: PO
Instructions: Maintenance, As Required

. It is of Synthetic origin and belongs to Salicylic Acid. It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action and also classified in Analgesics and Anti-inflammatory Agents pharmacological group.The Molecular Weight of Diflunisal is 250.20.

Diflunisal is contraindicated in conditions like Peptic ulcer,Bronchospasm,Renal diseases.

The severe or irreversible adverse effects of Diflunisal, which give rise to further complications include Gi bleeding, Stevens johnson syndrome, Jaundice, Renal failure, Gastric ulceration, Acute interstitial nephritis.The symptomatic adverse reactions produced by Diflunisal are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Tinnitus, GI symptoms.

Diflunisal is primarily indicated in conditions like Dental surgery, Dysmenorrhoea, Mild to moderate pain, Osteoarthritis, Pain, Rheumatoid arthritis, Sprains, Strains.

Diflunisal is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlprazolamAluminium Hydroxide and OxideAluminium Hydroxide and OxideAspirinHydrochlorothiazideIndomethacinDiflunisal increases the serum concentration of indomethacin upto two to three folds by inhibiting its renal metabolism and excretion thus increases the risk of toxicity such as gastrointestinal and CNS side effects.MajorCoadministration of these agents should be avoided.Magnesium Oxides and HydroxidesOxazepamParacetamolProbenecidSulindac These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Liver Function Test (LFT)

Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Tab Store Below 40°C. Protect from Sunlight and Moisture.

Diflunisal should be used with caution and lower daily dose in patients with kidney impairment. It should be used with caution in patients with compromised cardiac function, hypertension and other conditions pre-disposing to fluid retension.