Diethylcarbamazine (Citrate)

Diethylcarbamazine (Citrate) is anthelmintic agent. Diethylcarbamazine (Citrate) is used to treat filariasis (nematode infection).


Brands
Adult Dose
Dose: 0.357 to 2.5 mg/kg
Single Dose: 1.4 (1.4285)
Frequency: 24 hourly
Route: PO
Instructions: Initial
Neonatal
Dose: 1 mg/kg
Single Dose: 1 (1)
Frequency: 8 hourly
Route: Oral
Instructions: Initially for 3 days
Paedriatic
Dose: 1 mg/kg
Single Dose: 1 (1)
Frequency: 8 hourly
Route: Oral
Instructions: Initially for 3 days
Characteristics
. It is of Synthetic origin and belongs to Piperazine. It belongs to Anthelmintics pharmacological group.The Molecular Weight of Diethylcarbamazine (Citrate) is 391.40. Its pKa is 7.7.
Contraindications
Diethylcarbamazine (Citrate) is contraindicated in conditions like Hypersensitivity to murine proteins.
Effects
Diethylcarbamazine (Citrate) produces potentially life-threatening effects which include Conjunctivitis, Visual field loss, Encephalitis, Retinal hemorrhage, Mazzotti Reaction, Iridocyclitis. which are responsible for the discontinuation of Diethylcarbamazine (Citrate) therapy.The signs and symptoms that are produced after the acute overdosage of Diethylcarbamazine (Citrate) include Nausea, Vomiting, Drowsiness, Dizziness.The symptomatic adverse reactions produced by Diethylcarbamazine (Citrate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Drowsiness, Nausea, Fever, Chills, dizziness.
Indications
Diethylcarbamazine (Citrate) is primarily indicated in conditions like Filarial infection, Lymphatic filariasis, Onchoceriasis.
Interactions
Diethylcarbamazine (Citrate) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAcetazolamide (Na)Acetazolamide reduce urinary excretion and enhance pharmacological effect These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Liver Malfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store in a well closed container, at room temperature.
Warnings
Diethylcarbamazine should be used with caution in patients with renal impairment. Avoid use in infants, pregnant women, elderly or debiliated, especially in those with cardiac or renal disease. and in hyper sensitive pateints.
Back to List

Any information that appears on this website page is provided for the purpose of general information. This website has been compiled in good faith by HMIS.Online. However, no guarantee is made as to the completeness, validity or accuracy of the information it contains.