Conjugated Estrogens/Bazedoxifene

Conjugated estrogens are purified from pregnant mares'' urine and consist of the sodium salts of water-soluble estrogen sulfates blended to represent the average composition of material derived from pregnant mares'' urine. Conjugated estrogens are a mixture of sodium estrone sulfate and sodium equilin sulfate, and also contain as concomitant components, sodium sulfate conjugates, 17a-dihydroequilin, 17a-estradiol, and 17β-dihydroequilin. Bazedoxifene is supplied as the acetate salt (bazedoxifene acetate) and has the chemical name 1H-Indol-5-ol,1-[[4-[2-(hexahydro-1H-azepin-1-yl) ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-, monoacetate.it is used for the treatment of moderate to severe vasomotor symtoms and perventation of postmenopausal osteoporosis'

Brands
Adult Dose
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to sulfated steroids. . The Molecular Weight of conjugated Estrogens/Bazedoxifene is 372.41.
Contraindications
conjugated Estrogens/Bazedoxifene
Effects
The symptomatic adverse reactions produced by conjugated Estrogens/Bazedoxifene are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Nausea, Diarrhea, Abdominal pain, Dyspepsia, Neck pain, dizziness, dyspepsia, muscle spasm, oropharyngeal pain.
Indications
conjugated Estrogens/Bazedoxifene is primarily indicated in conditions like Menopausal symptoms, Postmenopausal osteoporosis.
Interactions
No data regarding the interactions of conjugated Estrogens/Bazedoxifene was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
tablet Store Between 20°C-25°C. Protect from Moisture.
Warnings
Women taking conjugated estrogen /bazedoxifen should not take progestins, additional estrogens or additional estrogen agonist/antagonists. Cardiovascular disorders, including venous thromboembolism, pulmonary embolism, stroke, and retinal vascular thrombosis. Malignant neoplasms, including endometrial cancer, breast cancer, and ovarian cancer. Estrogens increase the risk of gallbladder disease Discontinue estrogen if loss of vision, severe hypertriglyceridemia or cholestatic jaundice occur. Monitor thyroid function in women on thyroid replacement therapy .
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